El meloxicam subaracnoideo no inhibe la hipernocicepción mecánica en el test de la carragenina en ratones

Abstract

Background and objective

Evaluate the antinociceptive effects of subarachnoid meloxicam on the mechanical hypernociception induced by carrageenan in rats.

Methods

Randomized controlled trial. Eighteen adult male Wistar rats underwent a cannula implantation into the subarachnoid space and were randomly divided into two groups: group i received saline solution 5 μL, while group ii received meloxicam 30 μg. The mechanical hypernociception was induced by intraplantar injection of carrageenan and evaluated using a digital analgesymeter every 30 min during a 4 h period. The results were recorded as the Δ withdrawal threshold (in g), calculated by subtracting the measurement value after.

Results

The Δ withdrawal threshold mean values were lower in the group of patients treated with meloxicam over all time points between 45 and 165 min, however, there was no statistical significance (P = .835) for this difference.

Conclusion

Subarachnoid meloxicam at a dose of 30 μg.animal^–1 did not suppress the mechanical hypernociception in a model of inflammatory pain induced by intraplantar administration of carrageenan in rats. The data suggest that other dosages should be investigated the drug effect is discarded.