Claudia Gissi da Rocha Ferreira, Sérgio Bernardo Tenório
{"title":"Clonidina subaracnoidea y respuesta al trauma en cirugías cardíacas con circulación extracorpórea","authors":"Claudia Gissi da Rocha Ferreira, Sérgio Bernardo Tenório","doi":"10.1016/j.bjanes.2013.04.011","DOIUrl":null,"url":null,"abstract":"<div><h3>Background and objectives</h3><p>The intense trauma response triggered by cardiopulmonary bypass can lead to increased morbidity and mortality. The present study evaluated whether clonidine, a drug of the class of α-2 agonists, administered by spinal route, without association with local anesthetics or opioids, reduces this response in cardiac surgery with cardiopulmonary bypass.</p></div><div><h3>Method</h3><p>A total of 27 patients between 18 and 75 years old, divided by non-blinded fashion into a control group (15) and a clonidine group (12), were studied. All patients underwent identical technique of general anesthesia. Then, only the clonidine group received 1<!--> <!-->μg<!--> <!-->kg<sup>−1</sup> clonidine by spinal route. Levels of blood glucose, lactate and cortisol were measured at three consecutive times: T1, at the time of installation of invasive arterial pressure; T2, 10<!--> <!-->min after the first dose for cardioplegia; and T3, at the time of skin suture; and troponin<!--> <span>i</span> values at T1 and T3. The variation of results between T2-T1, T3-T2, and T3-T1 was also evaluated.</p></div><div><h3>Results</h3><p>There was a statistically significant difference only with respect to the variation in blood glucose in the clonidine group: T3-T2, <em>P</em> <!-->=<!--> <!-->.027, and T3-T1, <em>P</em> <!-->=<!--> <!-->.047.</p></div><div><h3>Conclusions</h3><p>Spinal clonidine at a dose of 1<!--> <!-->μg<!--> <!-->kg<sup>−1</sup> did not decrease blood measurements of troponin, cortisol, or lactate. Blood glucose suffered a more moderate variation during the procedure in the clonidine group. This fact, already reported in the literature, requires further investigation to be clarified.</p></div>","PeriodicalId":100199,"journal":{"name":"Brazilian Journal of Anesthesiology (Edicion en Espanol)","volume":"64 6","pages":"Pages 395-399"},"PeriodicalIF":0.0000,"publicationDate":"2014-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjanes.2013.04.011","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brazilian Journal of Anesthesiology (Edicion en Espanol)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S225549631400083X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Background and objectives
The intense trauma response triggered by cardiopulmonary bypass can lead to increased morbidity and mortality. The present study evaluated whether clonidine, a drug of the class of α-2 agonists, administered by spinal route, without association with local anesthetics or opioids, reduces this response in cardiac surgery with cardiopulmonary bypass.
Method
A total of 27 patients between 18 and 75 years old, divided by non-blinded fashion into a control group (15) and a clonidine group (12), were studied. All patients underwent identical technique of general anesthesia. Then, only the clonidine group received 1 μg kg−1 clonidine by spinal route. Levels of blood glucose, lactate and cortisol were measured at three consecutive times: T1, at the time of installation of invasive arterial pressure; T2, 10 min after the first dose for cardioplegia; and T3, at the time of skin suture; and troponin i values at T1 and T3. The variation of results between T2-T1, T3-T2, and T3-T1 was also evaluated.
Results
There was a statistically significant difference only with respect to the variation in blood glucose in the clonidine group: T3-T2, P = .027, and T3-T1, P = .047.
Conclusions
Spinal clonidine at a dose of 1 μg kg−1 did not decrease blood measurements of troponin, cortisol, or lactate. Blood glucose suffered a more moderate variation during the procedure in the clonidine group. This fact, already reported in the literature, requires further investigation to be clarified.