Diogo D.G. Bugano , Neda Kalhor , Jianjun Zhang , Michele Neskey , William N. William Jr
{"title":"Squamous-cell transformation in a patient with lung adenocarcinoma receiving erlotinib: Co-occurrence with T790M mutation","authors":"Diogo D.G. Bugano , Neda Kalhor , Jianjun Zhang , Michele Neskey , William N. William Jr","doi":"10.1016/j.ctrc.2015.03.007","DOIUrl":null,"url":null,"abstract":"<div><p>We report on a patient with metastatic lung adenocarcinoma who underwent testing for EGFR mutations in a pleural effusion that failed to show any alterations and received standard first and second-line chemotherapy. She received erlotinib as third-line therapy with a prolonged partial response. At time of progression, re-biopsy showed squamous cell carcinoma, supported by histology and immunohistochemistry. Molecular profiling confirmed EGFR exon 21 L858R and exon 20 T790M mutations. Squamous cell transformation should not defer EGFR re-sequencing.</p></div>","PeriodicalId":90461,"journal":{"name":"Cancer treatment communications","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ctrc.2015.03.007","citationCount":"13","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer treatment communications","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2213089615000146","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 13
Abstract
We report on a patient with metastatic lung adenocarcinoma who underwent testing for EGFR mutations in a pleural effusion that failed to show any alterations and received standard first and second-line chemotherapy. She received erlotinib as third-line therapy with a prolonged partial response. At time of progression, re-biopsy showed squamous cell carcinoma, supported by histology and immunohistochemistry. Molecular profiling confirmed EGFR exon 21 L858R and exon 20 T790M mutations. Squamous cell transformation should not defer EGFR re-sequencing.