The alterations in endometrial and myometrial transcriptome at the time of maternal recognition of pregnancy in pigs

Q1 Agricultural and Biological Sciences

Agri Gene Pub Date : 2016-12-01 DOI:10.1016/j.aggene.2016.09.004

B. Wojciechowicz, G. Kotwica, J. Kołakowska, K. Zglejc, M. Martyniak, A. Franczak

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引用次数: 10

Abstract

The maternal recognition of pregnancy in pigs occurs around day 12–13 of gestation. During this period embryo-derived signals act on the endometrium and the myometrium to trigger tissue-specific responses that lead to proper implantation and maintenance of pregnancy. The present study utilized gene expression microarrays to examine embryo-induced alterations in porcine endometrial and myometrial transcriptome on days 12–13 of pregnancy. It has been confirmed that the endometrium and the myometrium, in response to embryonic signals, express unique set of genes. However, a key discovery of this study is the fact that genes that encode crucial factors involved in maternal recognition of pregnancy and preparation of uterus for implantation are regulated similarly in both tissues. Genes responsible for PGs synthesis (PTGES2, PTGR2), uterine development and remodeling (HOXA10, GRB10, MTOR) and innate immune response and immunomodulation (NFKBIA, TRAFD1) were regulated similarly in the endometrium and the myometrium. This suggests that in pigs these tissues act in sync to support embryos during peri-implantation.

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猪母体妊娠识别时子宫内膜和子宫肌层转录组的改变

母猪对妊娠的识别发生在妊娠12-13天左右。在此期间，胚胎来源的信号作用于子宫内膜和肌层，触发组织特异性反应，导致适当的植入和维持妊娠。本研究利用基因表达微阵列检测了妊娠12-13天猪子宫内膜和子宫肌组织转录组的胚胎诱导改变。已经证实，子宫内膜和子宫肌层在响应胚胎信号时，表达了一组独特的基因。然而，本研究的一个关键发现是，编码参与母体妊娠识别和子宫植入准备的关键因子的基因在这两个组织中受到相似的调控。在子宫内膜和肌层中，负责PGs合成(PTGES2、PTGR2)、子宫发育和重塑(HOXA10、GRB10、MTOR)以及先天免疫反应和免疫调节(NFKBIA、TRAFD1)的基因受到相似的调控。这表明在猪体内，这些组织在胚胎着床期同步支持胚胎。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Agri Gene Agricultural and Biological Sciences-Agricultural and Biological Sciences (miscellaneous)

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期刊介绍： Agri Gene publishes papers that focus on the regulation, expression, function and evolution of genes in crop plants, farm animals, and agriculturally important insects and microorganisms. Agri Gene strives to be a diverse journal and topics in multiple fields will be considered for publication so long as their main focus is on agriculturally important organisms (plants, animals, insects, or microorganisms). Although not limited to the following, some examples of potential topics include: Gene discovery and characterization. Genetic markers to guide traditional breeding. Genetic effects of transposable elements. Evolutionary genetics, molecular evolution, population genetics, and phylogenetics. Profiling of gene expression and genetic variation. Biotechnology and crop or livestock improvement. Genetic improvement of biological control microorganisms. Genetic control of secondary metabolic pathways and metabolic enzymes of crop pathogens. Transcription analysis of beneficial or pest insect developmental stages Agri Gene encourages submission of novel manuscripts that present a reasonable level of analysis, functional relevance and/or mechanistic insight. Agri Gene also welcomes papers that have predominantly a descriptive component but improve the essential basis of knowledge for subsequent functional studies, or which provide important confirmation of recently published discoveries provided that the information is new.