Erratum to: ‘Serotonin uptake inhibitors modulate intracellular Ca2+ mobilization in platelets’ Eur. j. pharmacol. — Mol. pharmacol. sect. 288 (1995) 373–477

Abstract

The serotonin uptake inhibitors sertraline, paroxetine and fluoxetine were compared with imipramine and the calmodulin antagonists N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide (W-7) and calmidazolium, for their effects on intracellular Ca²⁺ mobilization in human platelets. All serotonin uptake inhibitors and calmodulin antagonists augmented thrombin-mediated increases in intracellular Ca²⁺. Sertraline, calmidazolium and W-7 also caused large dose-dependent increases in baseline levels of intracellular Ca²⁺. There was a rough correlation between the ability to elevate intracellular Ca²⁺ and potencies for inhibition of calmodulin. Neomycin, an inhibitor of inositol trisphosphate (IP₃) generation, significantly inhibited the effects of sertaline. This is consistent with a role of IP₃ and calmodulin in the effects of these drugs.