Simultaneous Detection of Dopamine and Paracetamol on Electroreduced Graphene Oxide–Cobalt Phthalocyanine Polymer Nanocomposite Electrode

IF 2.7 4区化学 Q3 CHEMISTRY, PHYSICAL

Electrocatalysis Pub Date : 2022-12-24 DOI:10.1007/s12678-022-00806-7

Charles Luhana, Philani Mashazi

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引用次数: 6

Abstract

The fabrication of sensitive, fast, cost-effective and eco-friendly electrochemical sensors is essential for monitoring analytes of biomedical, environmental and pharmaceutical interests. Herein, we report the simultaneous electroreduction and deposition of graphene oxide (GO) to form electrochemically reduced graphene oxide (ERGO) onto a glassy carbon electrode (GCE) represented as GCE-ERGO. Onto the GCE-ERGO, cobalt (II) tetra-amino phthalocyanine was electropolymerized to form a stable GCE-ERGO/polyCoTAPc. The sensing surface, GCE-ERGO/polyCoTAPc, was characterized using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) techniques to ascertain its electron transfer and conducting properties. The modifier surface functional groups and composition were confirmed using infrared spectroscopy and energy-dispersive X-ray spectroscopy. The prepared sensing electrode displayed enhanced electrocatalytic activity towards ferri/ferrocyanide {[Fe(CN)₆]^3−/4−} as a redox probe. GCE-ERGO/polyCoTAPc was further used for ultrasensitive simultaneous detection and determination of dopamine (DA) and paracetamol (PA). The electrocatalytic peak currents for DA and PA were greatly enhanced with an oxidation potential difference of 264 mV, wide enough for simultaneous determination. Using differential pulse voltammetry (DPV), the electrocatalytic oxidation peak currents of DA and PA at GCE-ERGO/polyCoTAPc showed linear dependence with the changes in concentrations up to 100 µM for DA and up to 90 µM for PA. The limits of detection (LOD) values were 0.095 µM and 0.10 µM using a signal-to-noise (S/N) ratio of 3 for DA and PA, respectively. The GCE-ERGO/polyCoTAPc displayed excellent sensitivity of 8.39 µA µM⁻¹ cm⁻² for DA and 1.32 µA µM⁻¹ cm⁻² for PA. The fabricated ultrasensitive electrochemical sensor was successfully used for the determination of DA and PA in synthetic urine samples with excellent percentage recoveries.

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电还原氧化石墨烯-酞菁钴聚合物纳米复合电极上多巴胺和扑热息痛的同时检测

摘要制备灵敏、快速、经济、环保的电化学传感器对于生物医学、环境和制药领域的分析物监测至关重要。在此，我们报道了氧化石墨烯(GO)的同时电还原和沉积，以形成电化学还原的氧化石墨烯(ERGO)到玻璃碳电极(GCE)上，表示为GCE-ERGO。在GCE-ERGO上，钴(II)四氨基酞菁电聚合形成稳定的GCE-ERGO/polyCoTAPc。利用循环伏安法(CV)和电化学阻抗谱(EIS)技术对传感表面GCE-ERGO/polyCoTAPc进行了表征，以确定其电子转移和导电性能。利用红外光谱和能量色散x射线光谱确定了改性剂的表面官能团和组成。所制备的传感电极对铁/亚铁氰化物{[Fe(CN)6]3−/4−}作为氧化还原探针表现出增强的电催化活性。进一步采用GCE-ERGO/polyCoTAPc超灵敏同时检测和测定多巴胺(DA)和扑热息痛(PA)。DA和PA的电催化峰电流明显增强，氧化电位差为264 mV，足以同时测定。采用差分脉冲伏安法(DPV)，在GCE-ERGO/polyCoTAPc上，DA和PA的电催化氧化峰电流随DA浓度≥100µM和PA浓度≥90µM的变化呈线性关系。DA和PA的检出限(LOD)分别为0.095µM和0.10µM，信噪比为3。GCE-ERGO/polyCoTAPc对DA的灵敏度为8.39µAµM−1 cm−2，对PA的灵敏度为1.32µAµM−1 cm−2。所制备的超灵敏电化学传感器成功地用于合成尿液样品中DA和PA的测定，并具有良好的回收率。

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来源期刊

Electrocatalysis CHEMISTRY, PHYSICAL-ELECTROCHEMISTRY

CiteScore

4.80

自引率

6.50%

发文量

审稿时长

>12 weeks

期刊介绍： Electrocatalysis is cross-disciplinary in nature, and attracts the interest of chemists, physicists, biochemists, surface and materials scientists, and engineers. Electrocatalysis provides the unique international forum solely dedicated to the exchange of novel ideas in electrocatalysis for academic, government, and industrial researchers. Quick publication of new results, concepts, and inventions made involving Electrocatalysis stimulates scientific discoveries and breakthroughs, promotes the scientific and engineering concepts that are critical to the development of novel electrochemical technologies. Electrocatalysis publishes original submissions in the form of letters, research papers, review articles, book reviews, and educational papers. Letters are preliminary reports that communicate new and important findings. Regular research papers are complete reports of new results, and their analysis and discussion. Review articles critically and constructively examine development in areas of electrocatalysis that are of broad interest and importance. Educational papers discuss important concepts whose understanding is vital to advances in theoretical and experimental aspects of electrochemical reactions.