Expression of multidrug-associated protein, P-glycoprotein, P53 and Bcl-2 proteins in bladder cancer and clinical implication.

Journal of Tongji Medical University = Tong ji yi ke da xue xue bao Pub Date : 2001-01-01 DOI:10.1007/BF02888038

Z Chen, Y Zhang, X Zhang, G Du, W Yang, Z Hu, J Li, Y Zhang

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Abstract

The expression of multidrug resistant proteins in bladder cancer and clinical implication was studied. Expression of multidrug-associated protein (MRP), P-glycoprotein (P-gp), P53 and Bcl-2 proteins were detected by using immunohistochemical method in 40 specimens of bladder transitional cell carcinoma. The results showed that the positive rate of MRP, P-gp, P53 and Bcl-2 was 52.5%, 57.5%, 47.5% and 62.5% respectively. The positive rate of MRP, P-gp, P53 and Bcl-2 in the grade I, II and III of tumors was 46.3%, 38.5%, 38.5%, 23.1%; 52.9%, 39.8%, 47.1%, 76.4%; 60.0%, 80.0%, 60.0%, 90.0% respectively. The positive rate of MRP, P-gp, P53 and Bcl-2 in 24 primary tumor specimens was 37.5%, 41.7%, 33.3%, 45.8% and that in 16 cases in recurrent specimens receiving chemotherapy 75.0%, 81.3%, 68.8%, 87.5% respectively. It was suggested the positive rate of MRP, P-gp, P53 and Bcl-2 was increased with the advance of tumor grade. The positive rate of four proteins in all recurrent cases was significantly increased (P < 0.05). The expression of MRP, P-gp, P53 and Bcl-2 proteins might be the important factors for chemotherapy failure.

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膀胱癌中多药相关蛋白、P-糖蛋白、P53 和 Bcl-2 蛋白的表达及其临床意义。

研究了膀胱癌中多药耐药蛋白的表达及其临床意义。采用免疫组化方法检测了40例膀胱过渡性细胞癌标本中多药相关蛋白（MRP）、P-糖蛋白（P-gp）、P53和Bcl-2蛋白的表达。结果显示，MRP、P-gp、P53 和 Bcl-2 的阳性率分别为 52.5%、57.5%、47.5% 和 62.5%。I、II和III级肿瘤中MRP、P-gp、P53和Bcl-2的阳性率分别为46.3%、38.5%、38.5%、23.1%；52.9%、39.8%、47.1%、76.4%；60.0%、80.0%、60.0%、90.0%。24例原发性肿瘤标本中MRP、P-gp、P53和Bcl-2的阳性率分别为37.5%、41.7%、33.3%和45.8%，16例接受化疗的复发性肿瘤标本中MRP、P-gp、P53和Bcl-2的阳性率分别为75.0%、81.3%、68.8%和87.5%。研究表明，随着肿瘤分级的升高，MRP、P-gp、P53 和 Bcl-2 的阳性率也随之升高。在所有复发病例中，四种蛋白的阳性率均显著升高（P < 0.05）。MRP、P-gp、P53和Bcl-2蛋白的表达可能是导致化疗失败的重要因素。

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Journal of Tongji Medical University = Tong ji yi ke da xue xue bao

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