V. P. Osipova, M. A. Polovinkina, A. D. Kolumbet, E. N. Kutlalieva, A. V. Velikorodov, N. T. Berberova
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引用次数: 0
Abstract
The antiradical activity of polycyclic compounds with indole and isoindole moieties was evaluated in vitro using a number of assays. All tested compounds, except for 3,5-di(tert-butyl)-4-hydroxybenzenecarbaldehyde N-(2-oxo-1,2-dihydro-3H-indole-3-ylidene)hydrazone, demonstrated much lower activity towards DPPH, ABTS•+, and NO• radicals than the well-known antioxidant ionol. All compounds showed a high radical-scavenging capacity relative to the superoxide radical anion generated in the enzymatic (NBT assay) and non-enzymatic (epinephrine autoxidation) systems. The high antiradical activity of 3,5-di(tert-butyl)-4-hydroxybenzenecarbaldehyde N-(2-oxo-1,2-dihydro-3H-indol-3-ylidene) hydrazone is attributable to the presence of 2,6-di-tert-butylphenol, indoline, and azine moieties, which promote the formation of a stable intermediate.
期刊介绍：
Doklady Chemistry is a journal that publishes new research in chemistry and chemical engineering of great significance. Initially the journal was a forum of the Russian Academy of Science and published only best contributions from Russia in the form of short articles. Now the journal welcomes submissions from any country in the English or Russian language. Every manuscript must be recommended by Russian or foreign members of the Russian Academy of Sciences.
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