Antigenotoxic and antioxidant activity in human chronic myelogenous leukaemia cell line K562 enhanced by Nitraria retusa leaf extracts

Abstract

Nitraria retusa leaf extracts have been investigated for their ability to induce antioxidant and antigenotoxic effects in a human chronic myelogenous leukaemia cell line. Antioxidant and antigenotoxic properties of N. retusa products were explored using antioxidant and the assays, respectively. Hex, Chl and MeOH extracts decreased oxidation induced by 2,2′-azobis (2-amidinopropane) dihydrochloride in human cells, with IC₅₀ concentrations of 0.6, 0.52 and 0.24 mg/mL, respectively, reflecting significant antioxidant potential. The same products inhibited the genotoxicity induced by hydroxyl radicals in the same human cell line, by 67% at 600 µg/mL, 74% at 780 µg/mL and 81.5% at 800 µg/mL, respectively.