Cationic and Anionic Antimicrobial Agents Co-Templated Mesostructured Silica Nanocomposites with a Spiky Nanotopology and Enhanced Biofilm Inhibition Performance
IF 31.6 1区 材料科学Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY
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引用次数: 8
Abstract
AbstractSection
Highlights
A ‘dual active templating’ strategy is firstly reported, using cationic and anionic bactericidal agents as co-templates for the preparation of antibacterial silica nanocomposite with spiky nanotopography.
The spiky nanocomposite exhibited enhanced antibacterial and biofilm inhibition performance, compared to pure antimicrobial cationic agent templated smooth silica nanocomposite.
AbstractSection
Abstract
Silica-based materials are usually used as delivery systems for antibacterial applications. In rare cases, bactericidal cationic surfactant templated silica composites have been reported as antimicrobial agents. However, their antibacterial efficacy is limited due to limited control in content and structure. Herein, we report a “dual active templating” strategy in the design of nanostructured silica composites with intrinsic antibacterial performance. This strategy uses cationic and anionic structural directing agents as dual templates, both with active antibacterial property. The cationic-anionic dual active templating strategy further contributes to antibacterial nanocomposites with a spiky surface. With controllable release of dual active antibacterial agents, the spiky nanocomposite displays enhanced anti-microbial and anti-biofilm properties toward Staphylococcus epidermidis. These findings pave a new avenue toward the designed synthesis of novel antibacterial nanocomposites with improved performance for diverse antibacterial applications.
期刊介绍:
Nano-Micro Letters is a peer-reviewed, international, interdisciplinary and open-access journal that focus on science, experiments, engineering, technologies and applications of nano- or microscale structure and system in physics, chemistry, biology, material science, pharmacy and their expanding interfaces with at least one dimension ranging from a few sub-nanometers to a few hundreds of micrometers. Especially, emphasize the bottom-up approach in the length scale from nano to micro since the key for nanotechnology to reach industrial applications is to assemble, to modify, and to control nanostructure in micro scale. The aim is to provide a publishing platform crossing the boundaries, from nano to micro, and from science to technologies.