C. English, J. Hastings, S. Hennessy, S. Dinneen, J. Crowley
{"title":"High prevalence of abnormal glucose regulation in patients presenting for routine coronary angiography","authors":"C. English, J. Hastings, S. Hennessy, S. Dinneen, J. Crowley","doi":"10.1002/PDI.1572","DOIUrl":null,"url":null,"abstract":"glucose metabolism is a known risk factor for coronary artery disease (CAD) and is frequently unrecognised even in patients with acute coronary syndrome. Patients with stable coronary symptoms frequently have multiple risk factors and may have no assessment of glucose regulation. The purpose of this study was to assess the prevalence of impaired glucose tolerance (IGT) and diabetes mellitus (DM) in a group of patients with stable symptoms presenting for coronary angiography. A modified oral glucose tolerance test (OGTT) was performed on 182 unselected patients undergoing elective angiography. Patients with known DM were excluded. Demographic data including cardiovascular risk factors, body mass index (BMI), and history of CAD were recorded. In all, 182 patients with a mean age of 62.1 years (±10.7 years) were studied. Indications for angiography were suspected angina. By WHO criteria an abnormal two-hour glucose was present in 49% of individuals, with 10.4% of these patients having overt DM. An abnormal two-hour glucose was seen in 63.2% of patients with significant CAD compared with 40.3% with normal or insignificant disease (p=0.004); 48.9% of patients with IGT or DM had normal fasting plasma glucose (FPG). In 78% of patients, BMI was over 25kg/m2. In this high risk population with multiple risk factors for CAD, previously undetected IGT and overt DM are very common. Almost two-thirds of patients with significant CAD had abnormal glucose regulation. The use of an FPG test alone may miss a significant number of patients with unrecognised glucose intolerance. Copyright © 2011 John Wiley & Sons. Practical Diabetes Int 2011; 28(3): 115-118","PeriodicalId":92116,"journal":{"name":"Practical diabetes international : the journal for diabetes care teams worldwide","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2011-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/PDI.1572","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Practical diabetes international : the journal for diabetes care teams worldwide","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/PDI.1572","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
常规冠状动脉造影患者血糖调节异常的高发率
葡萄糖代谢是冠状动脉疾病(CAD)的已知危险因素,即使在急性冠状动脉综合征患者中也经常被忽视。冠状动脉症状稳定的患者通常有多种危险因素,可能没有血糖调节评估。本研究的目的是评估一组症状稳定的冠状动脉造影患者中糖耐量受损(IGT)和糖尿病(DM)的患病率。对182例未选择的接受择期血管造影的患者进行改良的口服葡萄糖耐量试验(OGTT)。排除已知糖尿病患者。统计数据包括心血管危险因素、身体质量指数(BMI)和CAD病史。共纳入182例患者,平均年龄62.1岁(±10.7岁)。血管造影指征为疑似心绞痛。根据WHO标准,49%的个体存在两小时血糖异常,其中10.4%的患者有明显的糖尿病。63.2%的冠心病患者存在两小时血糖异常,而正常或不明显疾病的患者为40.3% (p=0.004);48.9%的IGT或DM患者空腹血糖(FPG)正常。78%的患者BMI大于25kg/m2。在具有多种冠心病危险因素的高危人群中,以前未检测到的IGT和显性糖尿病非常常见。几乎三分之二的冠心病患者血糖调节异常。单独使用FPG测试可能会遗漏大量未被识别的葡萄糖耐受不良患者。版权所有©2011 John Wiley & Sons。实用糖尿病杂志2011;28 (3): 115 - 118
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