Fast gas chromatography: The effect of fast temperature programming†

Abstract

Fast gas chromatography (GC) has been around ever since the introduction of capillary GC columns. M. Golay's patent application for capillary GC (Patent 2,920,478, January 12, 1960) showed five peaks in 15 s in 1957. Desty et al. (Desty, D. H.; Goldup, A.; Swanton, W. T. In Gas Chromatography; Brenner, N.; Caller, J. E.; Weiss, M. D., Eds.; Academic: New York, 1962; p. 105), LeClercq et al. (LeClercq, P. A.; Scherpenzeel, G. J.; Vermeer, E. A. A.; Cramers, C. A. J Chromatogr 1982, 241, 61–71), and Cramers et al. (Schutjes, C.; Vermeer, E.; Rijks, J.; Cramers, C. J Chromatogr 1982, 253, 1–16), among others, followed up this early work on fast GC. The work in this paper is a continuation of fast GC, primarily using fast oven temperature programming. This work is restricted to normal pressures, routinely used on Hewlett Packard 5890 and 6890 model gas chromatographs. The first step in doing fast GC is to reduce the column length, since the retention time is directly proportional to the length, only true for isothermal runs. Columns of 1 to 6 m are used and since this step sometimes sacrifices resolution, 100 μm inner diameter columns with thin films, 0.1 to 0.2 μm, are used with small sample sizes (split ratios of 500:1 to 2000:1). © 2000 John Wiley & Sons, Inc. J Micro Sep 12: 351–355, 2000