Health risk assessment of ethyl carbamate in fruit spirits.

IF 2.5 3区农林科学 Q2 CHEMISTRY, APPLIED

Food additives & contaminants. Part B, Surveillance Pub Date : 2023-10-26 DOI:10.1080/19393210.2023.2262956

Dejan Kusonić, Katarina Bijelić, Nebojša Kladar, Ljilja Torović, Branislava Srđenović Čonić

引用次数: 0

Abstract

Alcoholic beverages are multicomponent mixtures containing several carcinogenic compounds, including ethyl carbamate, which was evaluated in fruit spirits against the limit proposed by the International Alliance for Responsible Drinking (IARD) and then in terms of associated health. It was above the limit in 40% of the samples and statistically higher in stone fruit spirits. The MOE values below the limit were obtained for 49% and 98% of the samples at average and chronic heavy consumption by men, while for women the limit was reached by 19% and 96% of the samples, respectively. The lifetime cancer risk (LCR) approach based on the oral slope factor indicated risk concern for 96% of the samples at average consumption, regardless of gender, while LCR based on virtually safe dose indicated 25% and 69% of the samples posing a risk to women's and men's health, respectively. Preventive measures during spirit production and legal regulation of ethyl carbamate should be considered.

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果酒中氨基甲酸乙酯的健康风险评估。

酒精饮料是含有几种致癌化合物的多组分混合物，包括氨基甲酸乙酯，该化合物在果酒中根据国际负责任饮酒联盟（IARD）提出的限量进行了评估，然后根据相关健康进行了评估。在40%的样品中，它高于限值，在核果酒中，它在统计上更高。在男性平均和长期大量消费的情况下，49%和98%的样本的MOE值低于限值，而女性的MOE分别达到了19%和96%的限值。基于口服斜率因子的终身癌症风险（LCR）方法表明，96%的样本在平均消费时（无论性别）存在风险，而基于实际安全剂量的LCR方法表明，25%和69%的样本分别对女性和男性健康构成风险。应考虑在酒精生产过程中采取预防措施，并对氨基甲酸乙酯进行法律监管。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Food additives & contaminants. Part B, Surveillance 农林科学-毒理学

CiteScore

5.30

自引率

10.30%

发文量

审稿时长

2.7 months

期刊介绍： Food Additives & Contaminants: Part B publishes surveillance data indicating the presence and levels of occurrence of designated food additives, residues and contaminants in foods, food supplements and animal feed. Data using validated methods must meet stipulated quality standards to be acceptable and must be presented in a prescribed format for subsequent data-handling. Food Additives & Contaminants: Part B restricts its scope to include certain classes of food additives, residues and contaminants. This is based on a goal of covering those areas where there is a need to record surveillance data for the purposes of exposure and risk assessment. The scope is initially restricted to: Additives - food colours, artificial sweeteners, and preservatives; Residues – veterinary drug and pesticide residues; Contaminants – metals, mycotoxins, phycotoxins, plant toxins, nitrate/nitrite, PCDDs/PCFDs, PCBs, PAHs, acrylamide, 3-MPCD and contaminants derived from food packaging. Readership: The readership includes scientists involved in all aspects of food safety and quality and particularly those involved in monitoring human exposure to chemicals from the diet. Papers reporting surveillance data in areas other than the above should be submitted to Part A . The scope of Part B will be expanded from time-to-time to ensure inclusion of new areas of concern.