Unpacking the complexity of nuclear IL-33 (nIL-33): a crucial regulator of transcription and signal transduction.

IF 3.6 3区生物学 Q3 CELL BIOLOGY

Journal of Cell Communication and Signaling Pub Date : 2023-12-01 Epub Date: 2023-10-25 DOI:10.1007/s12079-023-00788-1

Zengbin Wang, Nanhong Tang

引用次数: 0

Abstract

Interleukin-33 (IL-33) (NF-HEV), a chromatin-associated nuclear cytokine, is a member of the IL-1 family. IL-33 possesses a nuclear localization signal and a homeodomain (a structure resembling a helix-turn-helix) that can bind to nuclear chromatin. Research has revealed that IL-33 can function as a nuclear factor to regulate various biological processes. This review discusses the cellular localization, functional effects, and immune regulation of full length IL-33 (FLIL-33), cytokine IL-33 (sIL-33) and nuclear IL-33 (nIL-33). In addition, the post-translational modifications of nIL-33 and the hypothesis of using nIL-33 as a treatment method were also summarized. A multidisciplinary approach is required which integrates methods and techniques from genomics, proteomics, cell biology and immunology to provide comprehensive insights into the function and therapeutic potential of nIL-33.

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揭示核IL-33 (nIL-33)的复杂性:转录和信号转导的关键调节因子。

白细胞介素33（IL-33）（NF-HEV）是一种染色质相关的核细胞因子，是IL-1家族的成员。IL-33具有核定位信号和可以与核染色质结合的同源结构域（类似螺旋-螺旋的结构）。研究表明，IL-33可以作为一种核因子调节各种生物过程。本文综述了全长IL-33（FLIL-33）、细胞因子IL-33（sIL-33）和细胞核IL-33（nIL-33）的细胞定位、功能作用和免疫调节。此外，还总结了nIL-33的翻译后修饰和使用nIL-33作为治疗方法的假设。需要一种多学科的方法，将基因组学、蛋白质组学、细胞生物学和免疫学的方法和技术相结合，以全面了解nIL-33的功能和治疗潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cell Communication and Signaling CELL BIOLOGY-

CiteScore

6.40

自引率

4.90%

发文量

期刊介绍： The Journal of Cell Communication and Signaling provides a forum for fundamental and translational research. In particular, it publishes papers discussing intercellular and intracellular signaling pathways that are particularly important to understand how cells interact with each other and with the surrounding environment, and how cellular behavior contributes to pathological states. JCCS encourages the submission of research manuscripts, timely reviews and short commentaries discussing recent publications, key developments and controversies. Research manuscripts can be published under two different sections : In the Pathology and Translational Research Section (Section Editor Andrew Leask) , manuscripts report original research dealing with celllular aspects of normal and pathological signaling and communication, with a particular interest in translational research. In the Molecular Signaling Section (Section Editor Satoshi Kubota) manuscripts report original signaling research performed at molecular levels with a particular interest in the functions of intracellular and membrane components involved in cell signaling.