{"title":"Solution and solid-state 33S NMR studies of 33S-labeled taurine","authors":"Yuichi Masuda, Shinobu Ohki, Yuuki Mogami, Kenzo Deguchi, Kenjiro Hashi, Atsushi Goto, Tadashi Shimizu, Kazuhiko Yamada","doi":"10.1002/mrc.5387","DOIUrl":null,"url":null,"abstract":"<p>Sulfur-33(<sup>33</sup>S) stable-isotope labeled taurine, 2-aminoethanesulfonic acid, has been synthesized, and a series of solution and solid-state <sup>33</sup>S nuclear magnetic resonance (NMR) experiments at 14.1 and 18.8 T, respectively, have been carried out at room temperature. The single peak of a solution <sup>33</sup>S NMR spectrum in 0.1-mM [<sup>33</sup>S]-taurine in D<sub>2</sub>O can be observed with the signal-to-noise (S/N) ratio of 9 in 40,000 scans, which paves the way toward in vivo analysis of pharmacokinetics and metabolism of <sup>33</sup>S-labeled taurine. Undistorted magic-angle-spinning (MAS) and static <sup>33</sup>S NMR spectra of polycrystalline [<sup>33</sup>S]-taurine are observed with sufficient S/N ratios for analysis, and the magnitudes of <sup>33</sup>S EFG and CS tensors can be obtained.</p>","PeriodicalId":18142,"journal":{"name":"Magnetic Resonance in Chemistry","volume":null,"pages":null},"PeriodicalIF":1.9000,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Magnetic Resonance in Chemistry","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/mrc.5387","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Sulfur-33(33S) stable-isotope labeled taurine, 2-aminoethanesulfonic acid, has been synthesized, and a series of solution and solid-state 33S nuclear magnetic resonance (NMR) experiments at 14.1 and 18.8 T, respectively, have been carried out at room temperature. The single peak of a solution 33S NMR spectrum in 0.1-mM [33S]-taurine in D2O can be observed with the signal-to-noise (S/N) ratio of 9 in 40,000 scans, which paves the way toward in vivo analysis of pharmacokinetics and metabolism of 33S-labeled taurine. Undistorted magic-angle-spinning (MAS) and static 33S NMR spectra of polycrystalline [33S]-taurine are observed with sufficient S/N ratios for analysis, and the magnitudes of 33S EFG and CS tensors can be obtained.
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MRC is devoted to the rapid publication of papers which are concerned with the development of magnetic resonance techniques, or in which the application of such techniques plays a pivotal part. Contributions from scientists working in all areas of NMR, ESR and NQR are invited, and papers describing applications in all branches of chemistry, structural biology and materials chemistry are published.
The journal is of particular interest not only to scientists working in academic research, but also those working in commercial organisations who need to keep up-to-date with the latest practical applications of magnetic resonance techniques.
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