Effect of coronary artery dynamics on the wall shear stress vector field topological skeleton in fluid–structure interaction analyses

IF 3.4 Q1 ENGINEERING, MECHANICAL
Harry J. Carpenter, Mergen H. Ghayesh, Anthony C. Zander, Peter J. Psaltis
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Abstract

In this paper, we investigate the impact of coronary artery dynamics on the wall shear stress (WSS) vector field topology by comparing fluid–structure interaction (FSI) and computational fluid dynamics (CFD) techniques. As one of the most common causes of death globally, coronary artery disease (CAD) is a significant economic burden; however, novel approaches are still needed to improve our ability to predict its progression. FSI can include the unique dynamical factors present in the coronary vasculature. To investigate the impact of these dynamical factors, we study an idealized artery model with sequential stenosis. The transient simulations made use of the hyperelastic artery and lipid constitutive equations, non-Newtonian blood viscosity, and the characteristic out-of-phase pressure and velocity distribution of the left anterior descending coronary artery. We compare changes to established metrics of time-averaged WSS (TAWSS) and the oscillatory shear index (OSI) to changes in the emerging WSS divergence, calculated here in a modified version to handle the deforming mesh of FSI simulations. Results suggest that the motion of the artery can impact downstream patterns in both divergence and OSI. WSS magnitude is also decreased by up to 57% due to motion in some regions. WSS divergence patterns varied most significantly between simulations over the systolic period, the time of the largest displacements. This investigation highlights that coronary dynamics could impact markers of potential CAD progression and warrants further detailed investigations in more diverse geometries and patient cases.

Abstract Image

流体-结构相互作用分析中冠状动脉动力学对壁剪切应力矢量场拓扑骨架的影响
在本文中,我们通过比较流体-结构相互作用(FSI)和计算流体动力学(CFD)技术,研究了冠状动脉动力学对壁剪切应力(WSS)矢量场拓扑的影响。作为全球最常见的死亡原因之一,冠状动脉疾病是一个巨大的经济负担;然而,仍然需要新的方法来提高我们预测其进展的能力。FSI可以包括存在于冠状血管系统中的独特的动力学因素。为了研究这些动力学因素的影响,我们研究了一个具有连续狭窄的理想化动脉模型。瞬态模拟利用了超弹性动脉和脂质本构方程、非牛顿血液粘度以及左前降支的特征异相压力和速度分布。我们将时间平均WSS(TAWSS)和振荡剪切指数(OSI)的既定指标的变化与新出现的WSS散度的变化进行比较,在这里以修改版本计算,以处理FSI模拟的变形网格。结果表明,动脉的运动可以影响分流和OSI的下游模式。由于某些区域的运动,WSS幅度也降低了57%。WSS发散模式在收缩期(最大位移的时间)的模拟之间变化最显著。这项研究强调,冠状动脉动力学可能会影响潜在CAD进展的标志物,并保证在更多样的几何形状和患者病例中进行进一步的详细研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
3.50
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