Detailed radiosynthesis of [18F]mG4P027 as a positron emission tomography radiotracer for mGluR4

IF 0.9 4区医学 Q4 BIOCHEMICAL RESEARCH METHODS

Journal of labelled compounds & radiopharmaceuticals Pub Date : 2023-01-02 DOI:10.1002/jlcr.4011

Junfeng Wang, Sung-Hyun Moon, Michael B. Cleary, Timothy M. Shoup, Georges El Fakhri, Zhaoda Zhang, Anna-Liisa Brownell

引用次数: 3

Abstract

We report here the detailed radiosynthesis of [¹⁸F]mG4P027, a metabotropic glutamate receptor 4 (mGluR4) PET radiotracer, which showed superior properties to the currently reported mGluR4 radiotracers. The radiosynthesis in the automated system has been challenging, therefore we disclose here the major limiting factors for the synthesis via step-by-step examination. And we hope this thorough study will help its automation for human use in the future.

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[18F]mG4P027作为mGluR4正电子发射断层扫描放射性示踪剂的详细放射合成

我们在此报道了[18F]mG4P027的详细放射合成，这是一种代谢型谷氨酸受体4（mGluR4）PET放射性示踪剂，其表现出优于目前报道的mGluR4-放射性示踪剂的特性。自动化系统中的放射合成一直具有挑战性，因此我们在这里通过逐步检查揭示了合成的主要限制因素。我们希望这项彻底的研究将有助于它的自动化在未来供人类使用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of labelled compounds & radiopharmaceuticals 医学-分析化学

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of Labelled Compounds and Radiopharmaceuticals publishes all aspects of research dealing with labeled compound preparation and applications of these compounds. This includes tracer methods used in medical, pharmacological, biological, biochemical and chemical research in vitro and in vivo. The Journal of Labelled Compounds and Radiopharmaceuticals devotes particular attention to biomedical research, diagnostic and therapeutic applications of radiopharmaceuticals, covering all stages of development from basic metabolic research and technological development to preclinical and clinical studies based on physically and chemically well characterized molecular structures, coordination compounds and nano-particles.