Assessment of liver fibrosis in patients with rheumatoid arthritis treated with methotrexate: Utility of fibroscan and biochemical markers in routine clinical practice
Andrea de Diego-Sola , Agustín Castiella Eguzkiza , Luis María López Domínguez , Iratxe Urreta Barallobre , María José Sánchez Iturri , Joaquín María Belzunegui Otaño , Eva María Zapata Morcillo
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引用次数: 0
Abstract
Objectives
To study the prevalence of liver fibrosis (LF) measured by FibroScan and APRI index in patients with rheumatoid arthritis (AR) undergoing treatment with methotrexate (MTX).
Methods
We included 59 patients with RA on MTX. Medical records, FibroScan measures and serological markers of liver damage were compared on the basis of cumulative methotrexate dose.
Results
Mean treatment duration was 82.4 ± 65.1 months and mean cumulative dose was 5214.5 ± 4031.9 mg. Five patients met LF criteria by fibroscan, while only one patient had a suggestive APRI score. No statistically significant differences were found in terms of LF measured by both APRI and fibroScan between patients with cumulative doses above and below 4000 mg. There was also no relationship between LF and treatment duration.
Conclusions
The occurrence of LF in patients with RA on MTX is a multifactorial process that does not seem directly related to its cumulative dose. FibroScan may be a useful technique in clinical practice to screen for this complication.
期刊介绍:
Una gran revista para cubrir eficazmente las necesidades de conocimientos en una patología de etiología, expresividad clínica y tratamiento tan amplios. Además es La Publicación Oficial de la Sociedad Española de Reumatología y del Colegio Mexicano de Reumatología y está incluida en los más prestigiosos índices de referencia en medicina.