Applicability of near-field electrospinning for the development of TCP-based thin fibres and scaffold 3D printing

IF 2.7 4区材料科学 Q1 MATERIALS SCIENCE, CERAMICS

Boletin de la Sociedad Espanola de Ceramica y Vidrio Pub Date : 2023-07-01 DOI:10.1016/j.bsecv.2022.05.003

M. García-Galán, F.J. Martínez-Vázquez , N. Rebollo-Muñoz, J.M. Montanero, P. Miranda

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引用次数: 0

Abstract

A novel method for obtaining ceramic (tricalcium phosphate, TCP) fibres with a small diameter (below 0.1 mm) is proposed and its potential use in the 3D printing of scaffolds for biomedical applications is explored. An ink consisting of a high solid content (40 vol%) ceramic slurry in a photocurable resin was prepared and extruded using near-field electrospinning. The influence of the electric potential, flow rate, and distance between tip and collector on the fabrication process in static mode were studied and the role played by unidirectional motion of the collector was also analyzed. A one order of magnitude reduction in the diameter of the jet to around 30 μm is demonstrated under static conditions, which increased to around 100 μm when collector was displaced. Continuous fibres were deposited but the slurry spread over the collector. The method was implemented on a DIW system, using in-flight UV light curing to prevent the spreading of the ink upon deposition. The feasibility of the strategy was demonstrated, although challenges remain for the optimization and control of the fabrication process. Nevertheless, these preliminary results suggest this could be a promising alternative to produce 3D ceramic scaffolds for biomedical applications with improved spatial resolution.

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近场静电纺丝在开发TCP基薄纤维和支架3D打印中的适用性

提出了一种获得小直径（小于0.1mm）陶瓷（磷酸三钙，TCP）纤维的新方法，并探索了其在生物医学支架3D打印中的潜在用途。制备由光固化树脂中的高固体含量（40vol%）陶瓷浆料组成的油墨，并使用近场静电纺丝挤出。研究了电势、流速和尖端与集电极之间的距离对静态模式下制造过程的影响，并分析了集电极单向运动所起的作用。在静态条件下，射流直径减少了一个数量级，降至约30μm，当收集器移位时，直径增加到约100μm。沉积了连续的纤维，但浆料在收集器上扩散。该方法在DIW系统上实施，使用飞行中的紫外线固化来防止沉积时油墨的扩散。尽管制造过程的优化和控制仍面临挑战，但该策略的可行性已得到证明。尽管如此，这些初步结果表明，这可能是一种很有前途的替代品，可以生产用于生物医学应用的3D陶瓷支架，并提高空间分辨率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Boletin de la Sociedad Espanola de Ceramica y Vidrio 工程技术-材料科学：硅酸盐

CiteScore

5.50

自引率

2.90%

发文量

审稿时长

103 days

期刊介绍： The Journal of the Spanish Ceramic and Glass Society publishes scientific articles and communications describing original research and reviews relating to ceramic materials and glasses. The main interests are on novel generic science and technology establishing the relationships between synthesis, processing microstructure and properties of materials. Papers may deal with ceramics and glasses included in any of the conventional categories: structural, functional, traditional, composites and cultural heritage. The main objective of the Journal of the Spanish Ceramic and Glass Society is to sustain a high standard research quality by means of appropriate reviewing procedures.