Alternative mechanisms of action of metallic nanoparticles to mitigate the global spread of antibiotic-resistant bacteria

Abstract

One of the biggest issues for medical professionals and a serious global concern is the emergence of multi-drug-resistant bacteria, which is the result of the overuse or misuse of antimicrobial agents. To combat this urgent problem, new drugs with alternative mechanisms of action are continuously replacing conventional antimicrobials. Nanotechnology-fueled innovations provide patients and medical professionals with hope for overcoming drug resistance. The aim of the present work was to document the antimicrobial potential and mechanisms of action of metallic nanoparticles against bacterial pathogens. Cell wall interaction and membrane penetration, reactive oxygen species (ROS) production, DNA damage, and protein synthesis inhibition were some of the generalised mechanisms recognised in the current study. In vitro and in vivo studies demonstrated that toxicity concerns and the development of bacterial resistance against nanoparticles (NPs) harden the use of metallic NP products for the treatment of drug-resistant bacterial pathogens. Therefore, researchers across the globe should actively engage in solving the above-mentioned issues.