An efficient electrochemical sensor based on transition metal sulfides for the detection of flufenamic acid

Chemistry of Inorganic Materials Pub Date : 2023-05-23 DOI:10.1016/j.cinorg.2023.100006

Rex Shanlee Santhiyagu Sahayaraj , Ruspika Sundaresan , Shen-Ming Chen , Balaji Ramachandran , Narendhar Chandrasekar

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Abstract

Transition metal sulfides (TMS) have been receiving specific attention due to their excellent physiochemical properties and electrochemical activity. In this article, we demonstrate the synthesis of sea-urchin-like Bi₂S₃ combined with MoS₂ hierarchical nanoflowers via a hydrothermal route for electrochemical sensing of Flufenamic acid (FMA). FMA is one of the non-steroidal anti-inflammatory drugs (NSAIDs) which endangers human health. The Bi₂S₃/MoS₂ composite's formation was confirmed by various characterizations via microscopic and spectroscopic techniques. The synergistic effect between the two metal sulfides improves electron transport and enables more active sites. Under optimal conditions, the resultant nanocomposite exhibits a high sensitivity value (0.44 μA μM⁻¹ cm⁻²), a reasonable limit of detection (0.009 μM), and a broad linear range (0.01 – 453 μM). Furthermore, the electrochemical detection of FMA in biological samples was achieved with good reliability and decent recovery.

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基于过渡金属硫化物的高效电化学传感器检测氟芬那酸

过渡金属硫化物（TMS）由于其优异的理化性质和电化学活性而受到特别关注。在这篇文章中，我们展示了通过水热途径合成海胆状Bi2S3与MoS2分级纳米花，用于Flufenamic acid（FMA）的电化学传感。FMA是一种危害人体健康的非甾体抗炎药。通过显微镜和光谱技术的各种表征证实了Bi2S3/MoS2复合材料的形成。两种金属硫化物之间的协同效应改善了电子传输，并使活性位点更多。在最佳条件下，所得纳米复合材料表现出高灵敏度值（0.44μAμM−1cm−2），一个合理的检测极限（0.009μM），以及宽的线性范围（0.01–453μM）。此外，生物样品中FMA的电化学检测具有良好的可靠性和良好的回收率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Chemistry of Inorganic Materials

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