Titration route affects biomimetic mineralization of carbonated hydroxyapatite bone material

IF 1.9 4区材料科学 Q3 Materials Science

Journal of the Australian Ceramic Society Pub Date : 2022-06-25 DOI:10.1007/s41779-022-00772-9

Bernard Owusu Asimeng, Emmanuel Obeng Agyen, Richard Asiamah, Obeng Gyasi Obed, Elvis Kwason Tiburu

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引用次数: 0

Abstract

Carbonated hydroxyapatite (CHAp) was prepared from snail shells calcined at 850 °C (calcined powder) and a diammonium hydrogen phosphate (DHP) solution for bone material. The titration route of the preparation was varied (route A and route B) to have two products (CHApA and CHApB). In route A, DHP solution was titrated against calcined powder (CP) solution to produce CHApA, whereas in route B, CP solution was titrated against DHP solution to produce CHApB. Thermogravimetric analysis-differential scanning calorimetry (TGA–DSC) showed different thermal profiles for the CHAps, which resulted in different morphologies that influenced mineralization. The mineralization studies of the CHAps were performed in simulated body fluid (SBF) for 7, 14, and 21 days. The X-ray fluorescence (XRF) data of the SBF solution before and after CHAp immersion showed that CHApB has higher dissolution of Ca and P minerals on day 14 than CHApA. Similarly, on day 21, the mineral uptake by the CHAp was higher in CHApB than in CHApA. Scanning electron microscopy (SEM) images showed spheroids and apatite-like bundles in CHApB but were absent in CHApA. In addition, X-ray diffractometry (XRD) and Fourier transform infrared (FTIR) spectroscopy confirmed the growth of carbonated apatite that started from day 14 to day 21. The findings indicate that the titration routes have a great influence on the formation of a highly resorbable material for bone implant coatings and augmentation applications.

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滴定途径影响碳酸羟基磷灰石骨材料的仿生矿化

摘要以850℃下煅烧的螺壳(煅烧粉)和磷酸氢二铵(DHP)溶液为骨材料制备了碳化羟基磷灰石(CHAp)。该制剂的滴定路线不同(A路线和B路线)，有两种产物(CHApA和CHApB)。在A路线中，DHP溶液与煅烧粉末(CP)溶液滴定生成CHApA，而在B路线中，CP溶液与DHP溶液滴定生成CHApB。热重分析-差示扫描量热分析(TGA-DSC)显示了不同的热剖面，导致不同的形态影响矿化。在模拟体液(SBF)中进行了7、14和21天的CHAps矿化研究。SBF溶液浸泡前后的x射线荧光(XRF)数据显示，CHApB在第14天对Ca和P矿物的溶解率高于CHApA。同样，在第21天，CHApB组的CHAp对矿物质的吸收高于CHApA组。扫描电镜(SEM)在CHApB中显示球状和磷灰石样束，而在CHApA中不存在。此外，x射线衍射(XRD)和傅里叶变换红外光谱(FTIR)证实了从第14天到第21天碳酸盐磷灰石的生长。研究结果表明，滴定路线对骨种植体涂层和增强应用中高度可吸收材料的形成有很大影响。

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来源期刊

Journal of the Australian Ceramic Society MATERIALS SCIENCE, CERAMICS-

CiteScore

3.20

自引率

5.30%

发文量

审稿时长

>12 weeks

期刊介绍： Publishes high quality research and technical papers in all areas of ceramic and related materials Spans the broad and growing fields of ceramic technology, material science and bioceramics Chronicles new advances in ceramic materials, manufacturing processes and applications Journal of the Australian Ceramic Society since 1965 Professional language editing service is available through our affiliates Nature Research Editing Service and American Journal Experts at the author''s cost and does not guarantee that the manuscript will be reviewed or accepted