Early and long-term results of surgical treatment of popliteal artery aneurysms using a heparin-bonded expanded polytetrafluorethilene graft.

Sara Speziali, Aaron T Fargion, Elena Giacomelli, Davide Esposito, Rossella DI Domenico, Serena DE Blasis, Gabriele Piffaretti, Carlo Pratesi, Walter Dorigo, Raffaele Pulli
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Abstract

Background: The aim of the present study was to assess early and long-term results of open surgical interventions for popliteal artery aneurysms (PAAs) with the use of heparin-bonded expanded polytetrafluorethylene (HePTFE) in a single center, retrospective, non-comparative cohort study.

Methods: A retrospective analysis of a prospectively maintained dataset, including 207 open interventions for PAAs between 2002 and 2022, was performed and 170 procedures carried on with the use of a HePTFE graft were found. Perioperative results were analyzed in terms of mortality, graft thrombosis and amputation rates. Follow-up results were analyzed in terms of survival, primary and secondary patency, freedom from amputation, freedom from reintervention with life-table analysis and Kaplan Meier curves. Follow-up results were considered as primary outcomes, whereas perioperative results were considered as secondary outcomes.

Results: In 82 interventions (48%) the PAA was asymptomatic. In 140 cases a medial approach was used, while in 30 cases a posterior approach was preferred. The level of the distal anastomosis was the p3 tract of the popliteal artery in 89% of the cases. One perioperative death occurred; early thromboses occurred in eight cases and the overall perioperative amputation rate was 2.8%. The median duration of follow-up was 48 months (range 1-251). Estimated survival rate at 10 years was 55% (standard error, SE, 0.065). The 10-year rates of primary and secondary patency and freedom from amputation were 40.8% (SE 0.06), 47.6% (SE 0.065) and 93.4% (SE 0.04), respectively. The estimated freedom from reintervention rate at 10 years was 57% (SE 0.05).

Conclusions: The results of this large monocentric experience showed that open surgical repair of PAAs with HePTFE is a safe procedure, with low rates of perioperative complications, and excellent results in the long-term setting.

肝素结合膨体聚四氟乙烯移植物治疗腘动脉瘤的早期和长期结果。
背景:本研究的目的是在一项单中心、回顾性、非比较性队列研究中,评估使用肝素结合膨胀聚四氟乙烯(HePTFE)对腘动脉瘤(PAAs)进行开放手术干预的早期和长期结果。方法:对前瞻性维护的数据集进行回顾性分析,包括2002年至2022年间207例PAA开放干预,发现170例使用HePTFE移植物进行的手术。根据死亡率、移植物血栓形成率和截肢率对围手术期结果进行分析。采用生命表分析和Kaplan-Meier曲线对随访结果进行生存率、一次和二次通畅率、无截肢、无再干预分析。随访结果被视为主要结果,而围手术期结果被认为是次要结果。结果:在82次干预中(48%)PAA无症状。140例患者采用内侧入路,30例患者首选后部入路。89%的病例的远端吻合水平为腘动脉p3束。围手术期死亡1例;8例患者出现早期血栓,围手术期截肢率为2.8%。中位随访时间为48个月(1-251)。10年的估计生存率为55%(标准误差,SE,0.065)。10年的原发性和继发性通畅率和无截肢率分别为40.8%(SE 0.06)、47.6%(SE 0.065)和93.4%(SE 0.04)。估计10年后无再干预率为57%(SE 0.05)。结论:这一大型单中心经验的结果表明,用HePTFE进行PAAs的开放手术修复是一种安全的手术,围手术期并发症发生率低,在长期环境中效果良好。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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