Predictor factors for recurrence in atypical meningiomas.

IF 1.2 4区 医学 Q4 DEVELOPMENTAL BIOLOGY
Andrei Ionuţ Cucu, Claudia Florida Costea, Şerban Turliuc, Laurenţiu Andrei Blaj, Iulian Prutianu, Gabriela Florenţa Dumitrescu, Cristina Gena Dascălu, Ion Poeată, Mihaela Coşman, Ana Cristina Istrate, Georgiana Macovei, Ligia Gabriela Tătăranu
{"title":"Predictor factors for recurrence in atypical meningiomas.","authors":"Andrei Ionuţ Cucu, Claudia Florida Costea, Şerban Turliuc, Laurenţiu Andrei Blaj, Iulian Prutianu, Gabriela Florenţa Dumitrescu, Cristina Gena Dascălu, Ion Poeată, Mihaela Coşman, Ana Cristina Istrate, Georgiana Macovei, Ligia Gabriela Tătăranu","doi":"10.47162/RJME.64.3.05","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and objectives: </strong>Atypical meningiomas (AMs), World Health Organization (WHO) grade 2, are a group of tumors with uneven and unpredictable clinical behavior. Our aim was to analyze possible tumor recurrence predictors, and to identify factors that improve progression-free survival (PFS).</p><p><strong>Patients, materials and methods: </strong>Our retrospective study included 81 patients followed up in the Prof. Dr. Nicolae Oblu Emergency Clinical Hospital, Iaşi, Romania, between 1 January 2010 and 31 December 2020. The histopathological specimens were reviewed according to the WHO 2021 criteria. Analyses included clinical, imaging, pathological and surgical factors.</p><p><strong>Results: </strong>The tumor recurred in 53.1% of the 81 cases within 60 months of surgery. Tumor location (p<0.000), tumor volume (p<0.010), extent of surgical resection (p<0.000) and dural sinus invasion (p<0.001) were predictive factors of recurrence. Gross total resection (Simpson grade I and II) was achieved in 59.2% of patients. Patients with the tumors located in the brain convexity and volume <26.4 cm³ had better survival rates up to recurrence. PFS showed a significant relationship between Simpson grade I-III and biopsy (p<0.000) and was statistically influenced by tumor volume and location, and dural sinus invasion.</p><p><strong>Conclusions: </strong>AMs are a heterogeneous group of tumors, and we identified posterior fossa location, volume ≥26.4 cm³, Simpson grade III and IV resection and dural sinus invasion as predictive factors for relapse and a shorter PFS. Whereas certain characteristics provide some prognostic value, future molecular characterizations of AMs are necessary, which will support the clinical decision-making process.</p>","PeriodicalId":54447,"journal":{"name":"Romanian Journal of Morphology and Embryology","volume":null,"pages":null},"PeriodicalIF":1.2000,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10720934/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Romanian Journal of Morphology and Embryology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.47162/RJME.64.3.05","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"DEVELOPMENTAL BIOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Background and objectives: Atypical meningiomas (AMs), World Health Organization (WHO) grade 2, are a group of tumors with uneven and unpredictable clinical behavior. Our aim was to analyze possible tumor recurrence predictors, and to identify factors that improve progression-free survival (PFS).

Patients, materials and methods: Our retrospective study included 81 patients followed up in the Prof. Dr. Nicolae Oblu Emergency Clinical Hospital, Iaşi, Romania, between 1 January 2010 and 31 December 2020. The histopathological specimens were reviewed according to the WHO 2021 criteria. Analyses included clinical, imaging, pathological and surgical factors.

Results: The tumor recurred in 53.1% of the 81 cases within 60 months of surgery. Tumor location (p<0.000), tumor volume (p<0.010), extent of surgical resection (p<0.000) and dural sinus invasion (p<0.001) were predictive factors of recurrence. Gross total resection (Simpson grade I and II) was achieved in 59.2% of patients. Patients with the tumors located in the brain convexity and volume <26.4 cm³ had better survival rates up to recurrence. PFS showed a significant relationship between Simpson grade I-III and biopsy (p<0.000) and was statistically influenced by tumor volume and location, and dural sinus invasion.

Conclusions: AMs are a heterogeneous group of tumors, and we identified posterior fossa location, volume ≥26.4 cm³, Simpson grade III and IV resection and dural sinus invasion as predictive factors for relapse and a shorter PFS. Whereas certain characteristics provide some prognostic value, future molecular characterizations of AMs are necessary, which will support the clinical decision-making process.

非典型脑膜瘤复发的预测因素。
背景与目的:世界卫生组织(世界卫生组织)2级非典型脑膜瘤(AM)是一组临床表现不均匀、不可预测的肿瘤。我们的目的是分析可能的肿瘤复发预测因素,并确定提高无进展生存率(PFS)的因素。患者、材料和方法:我们的回顾性研究包括2010年1月1日至2020年12月31日在罗马尼亚伊阿希的Nicolae Oblu教授-博士急诊临床医院随访的81名患者。根据世界卫生组织2021标准对组织病理学标本进行审查。分析包括临床、影像学、病理和手术因素。结果:81例患者术后60个月内肿瘤复发率为53.1%。肿瘤位置(结论:AM是一组异质性肿瘤,我们确定后窝位置、体积≥26.4cm³、Simpson III级和IV级切除和硬膜窦侵犯是复发和较短PFS的预测因素。尽管某些特征提供了一些预后价值,但AM的未来分子特征是必要的,这将支持临床决策ng过程。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
1.70
自引率
20.00%
发文量
221
审稿时长
3-8 weeks
期刊介绍: Romanian Journal of Morphology and Embryology (Rom J Morphol Embryol) publishes studies on all aspects of normal morphology and human comparative and experimental pathology. The Journal accepts only researches that utilize modern investigation methods (studies of anatomy, pathology, cytopathology, immunohistochemistry, histochemistry, immunology, morphometry, molecular and cellular biology, electronic microscopy, etc.).
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信