Influence of tumor topography on clinical-morphological profile of laryngeal malignancies.

IF 1.2 4区 医学 Q4 DEVELOPMENTAL BIOLOGY
Eduard Andrei Gheorghe, Iancu Emil Pleşea, Luminiţa Svetlana Welt, Georgian Hâlcu, Maria Camelia Foarfă, Iulică Ioniţă, Carmen Aurelia Mogoantă, Elena Ioniţă
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引用次数: 0

Abstract

Aim: Laryngeal cancers are redoubtable because they are still diagnosed in advanced stages which results in poor survival and the decline of life quality. The authors intend to identify if the tumor topography influences clinical behavior, the morphological profile and therapeutic strategy.

Patients, materials and methods: The study group included 188 patients with laryngeal malignancies diagnosed and treated in an Ear, Nose and Throat (ENT) Department. The patients have been divided into four groups according to the tumor topography and extension. Three categories of parameters were defined (epidemiological, clinical, and morphological) and analyzed comparatively between the four groups using filter scales and the χ² (chi-squared) correlation test.

Results: Epidemiological parameters (sex, age, socio-economic status) showed no significant differences between the four groups. Clinical parameters (symptoms, lymphadenopathies, surgical procedures, and hospitalization) instead registered significant differences between the four groups. Morphological parameters (longitudinal diameter, transverse diameter, shape, gross aspect, histopathological aspect, grade, local invasion - pT, lymph node invasion - pN, metastases - pM and tumor stage), excepting shape, registered too significant differences between the four groups. The analysis of the whole set of parameters in each group revealed different, distinct profiles for each of the topographic groups, especially for glottic and large tumors. Our results concerning the entire series of tumors ranged in the limits of variation of each of the parameters observed in the literature.

Conclusions: Our study revealed that tumors placed in different regions of the larynx have distinct profiles from epidemiological, clinical, and morphological points of view. However, the profile of our entire group of tumors proved to be comparable with the literature data.

肿瘤地形图对喉部恶性肿瘤临床形态特征的影响。
目的:喉癌是令人加倍的,因为它们仍然被诊断为晚期,这导致生存率低和生活质量下降。作者打算确定肿瘤地形图是否影响临床行为、形态学特征和治疗策略。患者、材料和方法:研究组包括188名在耳鼻喉科诊断和治疗的喉部恶性肿瘤患者。根据肿瘤的地形和范围,将患者分为四组。定义了三类参数(流行病学、临床和形态学),并使用过滤量表和χ²(卡方)相关检验对四组之间的参数进行了比较分析。结果:流行病学参数(性别、年龄、社会经济状况)在四组之间没有显著差异。临床参数(症状、淋巴结病、外科手术和住院治疗)在四组之间存在显著差异。形态参数(纵向直径、横向直径、形状、大体形态、组织病理学形态、分级、局部侵袭性pT、淋巴结侵袭性pN、转移性pM和肿瘤分期),除形状外,四组之间差异过大。对每组的整套参数的分析显示,每个地形组都有不同的、不同的轮廓,尤其是声门和大肿瘤。我们关于整个系列肿瘤的结果在文献中观察到的每个参数的变化范围内。结论:我们的研究表明,从流行病学、临床和形态学的角度来看,位于喉部不同区域的肿瘤有不同的特征。然而,我们整个肿瘤组的概况被证明与文献数据相当。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.70
自引率
20.00%
发文量
221
审稿时长
3-8 weeks
期刊介绍: Romanian Journal of Morphology and Embryology (Rom J Morphol Embryol) publishes studies on all aspects of normal morphology and human comparative and experimental pathology. The Journal accepts only researches that utilize modern investigation methods (studies of anatomy, pathology, cytopathology, immunohistochemistry, histochemistry, immunology, morphometry, molecular and cellular biology, electronic microscopy, etc.).
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