The importance of the circadian trough in glucocorticoid signaling: a variation on B-flat.

IF 2.6 4区心理学 Q2 BEHAVIORAL SCIENCES

Stress-The International Journal on the Biology of Stress Pub Date : 2023-11-01 Epub Date: 2023-10-30 DOI:10.1080/10253890.2023.2275210

Onno C Meijer, Sander Kooijman, Jan Kroon, Elizabeth M Winter

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引用次数: 0

Abstract

Glucocorticoid hormones are essential for health, but overexposure may lead to many detrimental effects, including metabolic, psychiatric, and bone disease. These effects may not only be due to increased overall exposure to glucocorticoids, but also to elevated hormone levels at the time of the physiological circadian trough of glucocorticoid levels. The late Mary Dallman developed a model that allows the differentiation between the effects of overall 24-hour glucocorticoid overexposure and the effects of a lack of circadian rhythmicity. For this, she continuously treated rats with a low dose of corticosterone (or "B"), which leads to a constant hormone level, without 24-hour overexposure using subcutaneously implanted pellets. The data from this "B-flat" model suggest that even modest elevations of glucocorticoid signaling during the time of the normal circadian trough of hormone secretion are a substantial contributor to the negative effects of glucocorticoids on health.

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昼夜节律谷在糖皮质激素信号传导中的重要性：B平面的变化。

糖皮质激素对健康至关重要，但过度暴露可能会导致许多有害影响，包括代谢、精神和骨病。这些影响不仅可能是由于对糖皮质激素的总体暴露增加，还可能是由于在糖皮质激素水平的生理昼夜节律低谷时激素水平升高。已故的Mary Dallman开发了一个模型，该模型可以区分24小时糖皮质激素过度暴露的影响和缺乏昼夜节律的影响。为此，她连续用低剂量皮质酮（或“B”）治疗大鼠，这会导致激素水平恒定，而不会使用皮下植入的颗粒24小时过度暴露。这个“B平面”模型的数据表明，即使在激素分泌的正常昼夜节律低谷期间，糖皮质激素信号的适度升高也是糖皮质激素对健康产生负面影响的重要原因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Stress-The International Journal on the Biology of Stress 医学-行为科学

CiteScore

5.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The journal Stress aims to provide scientists involved in stress research with the possibility of reading a more integrated view of the field. Peer reviewed papers, invited reviews and short communications will deal with interdisciplinary aspects of stress in terms of: the mechanisms of stressful stimulation, including within and between individuals; the physiological and behavioural responses to stress, and their regulation, in both the short and long term; adaptive mechanisms, coping strategies and the pathological consequences of stress. Stress will publish the latest developments in physiology, neurobiology, molecular biology, genetics research, immunology, and behavioural studies as they impact on the understanding of stress and its adverse consequences and their amelioration. Specific approaches may include transgenic/knockout animals, developmental/programming studies, electrophysiology, histochemistry, neurochemistry, neuropharmacology, neuroanatomy, neuroimaging, endocrinology, autonomic physiology, immunology, chronic pain, ethological and other behavioural studies and clinical measures.