Proteomics in the study of female fertility: an update.

IF 3.8 3区生物学 Q1 BIOCHEMICAL RESEARCH METHODS

Expert Review of Proteomics Pub Date : 2023-07-01 Epub Date: 2023-12-30 DOI:10.1080/14789450.2023.2275683

Vasiliki Kanaka, Petros Drakakis, Dimitrios Loutradis, George Th Tsangaris

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引用次数: 0

Abstract

Introduction: Female fertility has been a field of interest for the scientific community throughout the years. The contribution of proteomics in the study of female fertility as well as female infertility and in vitro fertilization (IVF) has been significant. Proteomics is a recently developed field, extensively applied to the identification and quantification of proteins, which could be used as potential biomarkers in a diagnostic, prognostic, or predictive manner in a variety of medical conditions.

Areas covered: The present review focuses on proteomic studies of the oocyte and endometrial environment as well as on conditions related to infertility, such as polycystic ovarian syndrome, endometriosis, obesity, and unexplained infertility. Moreover, this review presents studies that have been done in an effort to search for fertility biomarkers in individuals following the IVF procedure.

Expert opinion: The comprehension of the molecular pathways behind female fertility and infertility could contribute to the diagnosis, prognosis, and prediction of infertility. Moreover, the identification of proteomic biomarkers for IVF cycles could predict the possible outcome of an IVF cycle, prevent an unsuccessful IVF, and monitor the IVF cycle in a personalized manner, leading to increased success rates. [Figure: see text].

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女性生育能力研究中的蛋白质组学：最新进展。

引言：多年来，女性生育一直是科学界感兴趣的领域。蛋白质组学在研究女性生育能力、女性不孕不育和体外受精（IVF）方面做出了重大贡献。蛋白质组学是最近发展起来的一个领域，广泛应用于蛋白质的鉴定和定量，这些蛋白质可以在各种医疗条件下以诊断、预后或预测的方式用作潜在的生物标志物。涵盖领域：本综述侧重于卵母细胞和子宫内膜环境的蛋白质组学研究，以及与不孕相关的疾病，如多囊卵巢综合征、子宫内膜异位症、肥胖和不明原因不孕。此外，这篇综述介绍了为寻找试管婴儿手术后个体的生育生物标志物而进行的研究。专家意见：了解女性生育和不孕背后的分子途径有助于不孕的诊断、预后和预测。此外，体外受精周期蛋白质组生物标志物的鉴定可以预测体外受精周期的可能结果，防止体外受精失败，并以个性化的方式监测体外受精周期，从而提高成功率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Proteomics 生物-生化研究方法

CiteScore

7.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Expert Review of Proteomics (ISSN 1478-9450) seeks to collect together technologies, methods and discoveries from the field of proteomics to advance scientific understanding of the many varied roles protein expression plays in human health and disease. The journal coverage includes, but is not limited to, overviews of specific technological advances in the development of protein arrays, interaction maps, data archives and biological assays, performance of new technologies and prospects for future drug discovery. The journal adopts the unique Expert Review article format, offering a complete overview of current thinking in a key technology area, research or clinical practice, augmented by the following sections: Expert Opinion - a personal view on the most effective or promising strategies and a clear perspective of future prospects within a realistic timescale Article highlights - an executive summary cutting to the author''s most critical points.