Prateek Singh, Shweta Sharma, Pramod Kumar Sharma, Aftab Alam
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引用次数: 0
Abstract
Background: Patients with diabetes suffer from major complications like Diabetic Retinopathy, Diabetic Coronary Artery Disease, and Diabetic Foot ulcers (DFUs). Diabetes complications are a group of ailments whose recovery time is especially delayed, irrespective of the underlying reason. The longer duration of wound healing enhances the probability of problems like sepsis and amputation. The delayed healing makes it more critical for research focus. By understanding the molecular pathogenesis of diabetic wounds, it is quite easy to target the molecules involved in the healing of wounds. Recent research on beta-adrenergic blocking drugs has revealed that these classes of drugs possess therapeutic potential in the healing of DFUs. However, because the order of events in defective healing is adequately defined, it is possible to recognize moieties that are currently in the market that are recognized to aim at one or several identified molecular processes.
Objective: The aim of this study was to explore some molecules with different therapeutic categories that have demonstrated favorable effects in improving diabetic wound healing, also called the repurposing of drugs.
Method: Various databases like PubMed/Medline, Google Scholar and Web of Science (WoS) of all English language articles were searched, and relevant information was collected regarding the role of beta-adrenergic blockers in diabetic wounds or diabetic foot ulcers (DFUs) using the relevant keywords for the literature review.
Result: The potential beta-blocking agents and their mechanism of action in diabetic foot ulcers were studied, and it was found that these drugs have a profound effect on diabetic foot ulcer healing as per reported literatures.
Conclusion: There is a need to move forward from preclinical studies to clinical studies to analyze clinical findings to determine the effectiveness and safety of some beta-antagonists in diabetic foot ulcer treatment.
背景：糖尿病患者患有糖尿病视网膜病变、糖尿病冠状动脉疾病和糖尿病足溃疡（DFU）等主要并发症。糖尿病并发症是一组恢复时间特别延迟的疾病，无论其根本原因如何。伤口愈合的持续时间越长，出现败血症和截肢等问题的可能性就越大。延迟的愈合使其成为研究重点的关键。通过了解糖尿病伤口的分子发病机制，很容易靶向参与伤口愈合的分子。最近对β-肾上腺素能阻断药物的研究表明，这类药物在DFU的愈合方面具有治疗潜力。然而，由于缺陷愈合中的事件顺序得到了充分的定义，因此有可能识别出目前市场上公认的针对一个或几个已识别的分子过程的部分。目的：本研究的目的是探索一些具有不同治疗类别的分子，这些分子在改善糖尿病伤口愈合方面表现出良好的效果，也称为药物的再利用。方法：检索PubMed/Medline、Google Scholar和Web of Science（WoS）等所有英文文章的数据库，并使用相关关键词收集有关β-肾上腺素能阻滞剂在糖尿病伤口或糖尿病足溃疡（DFU）中的作用的相关信息，进行文献综述。结果：研究了糖尿病足溃疡的潜在β-阻断剂及其作用机制，据文献报道，这些药物对糖尿病足溃疡愈合有深远影响。结论：有必要从临床前研究转向临床研究，分析临床结果，以确定某些β-拮抗剂治疗糖尿病足溃疡的有效性和安全性。
期刊介绍：
Current Diabetes Reviews publishes frontier reviews on all the latest advances on diabetes and its related areas e.g. pharmacology, pathogenesis, complications, epidemiology, clinical care, and therapy. The journal"s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians who are involved in the field of diabetes.
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