Variability of cardioinhibition in vasovagal syncope: differences between subgroups during cardioinhibition and beyond.

IF 3.9 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Autonomic Research Pub Date : 2023-12-01 Epub Date: 2023-10-24 DOI:10.1007/s10286-023-00991-5

Ineke A van Rossum, Frederik J de Lange, David G Benditt, Erik W van Zwet, Marc van Houwelingen, Roland D Thijs, J Gert van Dijk

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引用次数: 0

Abstract

Purpose: We compared hemodynamic parameters between subjects with marked, intermediate and minimal cardioinhibition during vasovagal syncope.

Methods: The study included subjects with a decrease in heart rate while experiencing a complete vasovagal syncope during tilt-table testing. The subjects were classified as having marked, intermediate or minimal cardioinhibition, based on tertile values of the decrease in heart rate. Hemodynamic parameters between these groups were compared before tilt in the supine position, shortly after tilt and during cardioinhibition.

Results: A total of 149 subjects with a median age of 43 (interquartile range 24-60) years were included in the study. Among the three groups with different levels of cardioinhibition, the highest heart rate was observed in subjects with marked cardioinhibition both before and shortly after tilt and at the start of cardioinhibition. The heart rate decrease in these subjects was both larger and faster compared to subjects with minimal and intermediate cardioinhibition.

Conclusion: Subjects with marked cardioinhibition have both a larger and faster decrease in heart rate compared to subjects with intermediate and minimal cardioinhibition, as early as from the start of cardioinhibition. Marked cardioinhibition is related to differences in hemodynamic profiles already present well before the start of cardioinhibition.

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血管迷走性晕厥心脏抑制的变异性：心脏抑制期间和之后亚组之间的差异。

目的：我们比较了血管迷走性晕厥期间有明显、中度和轻度心脏抑制的受试者的血液动力学参数。方法：该研究纳入了在倾斜台测试中出现完全性血管迷走性晕厥时心率下降的受试者。根据心率下降的三分位数，受试者被分为具有显著、中等或最小的心脏抑制。在仰卧位倾斜前、倾斜后不久和心脏抑制期间比较这些组之间的血液动力学参数。结果：共有149名中位年龄为43岁（四分位间距24-60）的受试者被纳入研究。在具有不同心脏抑制水平的三组中，在倾斜前、倾斜后不久以及心脏抑制开始时，具有明显心脏抑制的受试者的心率最高。与轻度和中度心脏抑制的受试者相比，这些受试者的心率下降幅度更大、速度更快。结论：与中度和轻度心脏抑制的受试者相比，早在心脏抑制开始时，具有显著心脏抑制的患者心率下降幅度更大、速度更快。明显的心脏抑制与早在心脏抑制开始之前就已经存在的血液动力学特征的差异有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Autonomic Research 医学-临床神经学

CiteScore

7.40

自引率

6.90%

发文量

审稿时长

>12 weeks

期刊介绍： Clinical Autonomic Research aims to draw together and disseminate research work from various disciplines and specialties dealing with clinical problems resulting from autonomic dysfunction. Areas to be covered include: cardiovascular system, neurology, diabetes, endocrinology, urology, pain disorders, ophthalmology, gastroenterology, toxicology and clinical pharmacology, skin infectious diseases, renal disease. This journal is an essential source of new information for everyone working in areas involving the autonomic nervous system. A major feature of Clinical Autonomic Research is its speed of publication coupled with the highest refereeing standards.