Preventive strategies in familial and hereditary colorectal cancer

IF 3.2 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Zachariah H. Foda , Pooja Dharwadkar , Bryson W. Katona
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引用次数: 0

Abstract

Colorectal cancer is a leading cause of cancer-related deaths worldwide. While most cases are sporadic, a significant proportion of cases are associated with familial and hereditary syndromes. Individuals with a family history of colorectal cancer have an increased risk of developing the disease, and those with hereditary syndromes such as Lynch syndrome or familial adenomatous polyposis have a significantly higher risk. In these populations, preventive strategies are critical for reducing the incidence and mortality of colorectal cancer. This review provides an overview of current preventive strategies for individuals at increased risk of colorectal cancer due to familial or hereditary factors. The manuscript includes a discussion of risk assessment and genetic testing, highlighting the importance of identifying at-risk individuals and families. This review describes various preventive measures, including surveillance colonoscopy, chemoprevention, and prophylactic surgery, and their respective benefits and limitations. Together, this work highlights the importance of preventive strategies in familial and hereditary colorectal cancer.

家族性和遗传性癌症的预防策略。
癌症是全球癌症相关死亡的主要原因。虽然大多数病例是散发性的,但很大一部分病例与家族性和遗传性综合征有关。有结直肠癌癌症家族史的个体患结直肠癌的风险增加,而那些患有遗传综合征(如林奇综合征或家族性腺瘤性息肉病)的个体患该疾病的风险明显更高。在这些人群中,预防策略对于降低癌症的发病率和死亡率至关重要。这篇综述概述了目前因家族或遗传因素而增加结直肠癌癌症风险的个体的预防策略。这份手稿包括对风险评估和基因检测的讨论,强调了识别高危个人和家庭的重要性。这篇综述描述了各种预防措施,包括监测结肠镜检查、化学预防和预防性手术,以及它们各自的益处和局限性。这项工作共同强调了家族性和遗传性癌症预防策略的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.50
自引率
0.00%
发文量
23
审稿时长
69 days
期刊介绍: Each topic-based issue of Best Practice & Research Clinical Gastroenterology will provide a comprehensive review of current clinical practice and thinking within the specialty of gastroenterology.
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