Effect of vitamin D supplementation on management of anemia in hemodialysis patients with vitamin D deficiency: A double-blind, randomized, controlled trial

IF 1.2 4区医学 Q3 UROLOGY & NEPHROLOGY

Hemodialysis International Pub Date : 2023-10-18 DOI:10.1111/hdi.13121

Sameh Mohamed Emarah, Mohamed Abd El Rahman Ahmed, Ghada Mohamed El Kannishy, Ahmed Elsaeed Abdulgalil

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引用次数: 0

Abstract

Introduction

Anemia and vitamin D deficiency are common problems among hemodialysis (HD) patients. This study aimed to assess the impact of correction of vitamin D deficiency with vitamin D supplementation on the improvement of anemia in patients with end-stage renal disease (ESRD) on maintenance HD.

Methods

This double-blind, randomized, controlled study included 100 anemic HD patients with vitamin D deficiency who were randomly divided using the closed envelop method into two groups (1:1). The first group received vitamin D (50,000 IU) monthly for 6 months, and the other group received a placebo for the same period. 25-Hydroxyvitamin D (25(OH)D) levels were measured for both groups at the beginning of the study and after 6 months at the end of the study. Hemoglobin (Hb) concentrations were recorded monthly.

Findings

Vitamin D supplementation during the period of the study increased 25(OH)D levels in the vitamin D group more than the placebo group (p > 0.001). Serum ferritin, serum iron, and transferrin saturation did not differ significantly between both groups during the period of the study. Hb concentration in the vitamin D group increased more than that in the other group over the period of the study, and there was a statistically significant difference between the two groups in all durations of follow-up. Erythropoietin (EPO) dosage requirements were found to be lower in the vitamin D group than in the placebo group, and this was statistically significant (p > 0.001).

Discussion

Vitamin D supplementation in anemic ESRD patients on HD with vitamin D deficiency or insufficiency is safe and effective in improving anemia and decreasing EPO dosage.

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补充维生素D对维生素D缺乏血液透析患者贫血治疗的影响：一项双盲、随机、对照试验。

简介：贫血和维生素D缺乏是血液透析（HD）患者的常见问题。本研究旨在评估补充维生素D纠正维生素D缺乏对终末期肾病（ESRD）患者贫血改善的影响。第一组接受了维生素D（50000 IU）每月6次月，另一组在同一时期接受安慰剂治疗。在研究开始时和6 研究结束时的几个月。每月记录血红蛋白（Hb）浓度。研究结果：在研究期间补充维生素D使维生素D组的25（OH）D水平比安慰剂组增加更多（p > 0.001）。在研究期间，两组之间的血清铁蛋白、血清铁和转铁蛋白饱和度没有显著差异。在研究期间，维生素D组的Hb浓度比另一组增加得更多，在所有随访时间内，两组之间存在统计学显著差异。维生素D组对促红细胞生成素（EPO）的剂量要求低于安慰剂组，这具有统计学意义（p > 0.001）。讨论：在患有维生素D缺乏或不足的HD的贫血ESRD患者中补充维生素D在改善贫血和减少EPO剂量方面是安全有效的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hemodialysis International UROLOGY & NEPHROLOGY-

CiteScore

2.50

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Hemodialysis International was originally an annual publication containing the Proceedings of the International Symposium on Hemodialysis held in conjunction with the Annual Dialysis Conference. Since 2003, Hemodialysis International is published quarterly and contains original papers on clinical and experimental topics related to dialysis in addition to the Annual Dialysis Conference supplement. This journal is a must-have for nephrologists, nurses, and technicians worldwide. Quarterly issues of Hemodialysis International are included with your membership to the International Society for Hemodialysis. The journal contains original articles, review articles, and commentary to keep readers completely updated in the field of hemodialysis. Edited by international and multidisciplinary experts, Hemodialysis International disseminates critical information in the field.