The effect of Oxytocin administration on patient-therapist alliance congruence: Results from a randomized controlled trial.

IF 2.6 1区心理学 Q2 PSYCHOLOGY, CLINICAL

Psychotherapy Research Pub Date : 2024-11-01 Epub Date: 2023-10-19 DOI:10.1080/10503307.2023.2269300

Ariella Grossman-Giron, Hadar Fisher, Dana Atzil-Slonim, Hagai Maoz, Uri Nitzan, Dana Tzur Bitan

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引用次数: 0

Abstract

Objectives: The effects of oxytocin (OT) administration on psychotherapeutic processes have thus far been elusive. This study explored the effect of OT administration on patient-therapist congruence of the working alliance.

Method: Inpatients with mental disorders (N = 87) participating in a randomized controlled trial received OT (n = 44) or placebo (n = 43) intranasally twice a day, for four weeks. Patients and therapists rated the alliance after each session.

Results: Oxytocin significantly moderated the level of agreement (b = -0.56, SE = 0.25, t = -2.30, p = 0.02), such that patients receiving OT demonstrated lower discrepancy (b = -0.73, p < 0.001) than did those receiving placebo (b = -1.30, p < 0.001). On the other hand, the mutual covariance of patient-therapist ratings across sessions was positive and significant for patients receiving placebo (b = 0.26, p = 0.01) but not for patients in the OT group (b = -0.06, p = .56).

Conclusion: Oxytocin can reduce discrepancies of patient-therapist perceptions of the alliance, although additional studies are needed to explore OT's effect on alliance development over time. As alliance congruence is associated with therapy outcomes, such intervention may lead to enhancement of therapeutic gains.

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催产素给药对患者-治疗师联盟一致性的影响：一项随机对照试验的结果。

目的：到目前为止，催产素（OT）给药对心理治疗过程的影响尚不明确。本研究探讨了OT管理对工作联盟患者-治疗师一致性的影响。方法：住院精神障碍患者（N = 87）接受OT（n = 44）或安慰剂（n = 43）鼻内给药，每天两次，持续四周。患者和治疗师在每次治疗后对联盟进行评分。结果：催产素显著降低了一致性水平（b = -0.56，SE = 0.25，吨 = -2.30，第页 = 0.02），使得接受OT的患者表现出较低的差异（b = -0.73，p b = -1.30，p b = 0.26，p = 0.01），但对于OT组的患者没有（b = -0.06，p = .56）。结论：催产素可以减少患者-治疗师对联盟的认知差异，尽管还需要更多的研究来探索OT对联盟发展的影响。由于联盟一致性与治疗结果有关，这种干预可能会提高治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychotherapy Research PSYCHOLOGY, CLINICAL-

CiteScore

7.80

自引率

10.30%

发文量

期刊介绍： Psychotherapy Research seeks to enhance the development, scientific quality, and social relevance of psychotherapy research and to foster the use of research findings in practice, education, and policy formulation. The Journal publishes reports of original research on all aspects of psychotherapy, including its outcomes, its processes, education of practitioners, and delivery of services. It also publishes methodological, theoretical, and review articles of direct relevance to psychotherapy research. The Journal is addressed to an international, interdisciplinary audience and welcomes submissions dealing with diverse theoretical orientations, treatment modalities.