Kinetics and efficacy of photo-activated crosslink for tissue-engineering

Jui-Teng Lin
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引用次数: 1

Abstract

We will review the kinetics, applications and efficacy of light-activated crosslink. The crosslink efficacy is influenced by multiple factors including: the applied light intensity, exposure period and dose, the initial concentration profiles of photosensitizers (PS) and oxygen, the quantum yield of the PS triplet state, the kinetic rate constants of PS (in type-I) and oxygen concentration (in typeII). Lower light intensity (I0) and higher PS concentration (C0) provides higher efficacy, but also suffers more toxicity to the cells. Higher light intensity (I0) may accelerate the crosslink but has lower efficacy (for the same dose). Therefore, optimal ratio of C0/ I0 is required for accelerated and safe crosslink. Safety issue also limits the maximum dose can be applied to the collagen, besides the limitation of PS concentration. Three important issues are presented: improvement of the crosslink speed (via higher light intensity) and efficacy of crosslink, and the role of photosensitizer (photo initiator) concentration.
光活化交联在组织工程中的动力学与性能
我们将综述光活化交联的动力学、应用和功效。交联效果受到多种因素的影响,包括:施加的光强度、暴露时间和剂量、光敏剂(PS)和氧的初始浓度分布、PS三重态的量子产率、PS的动力学速率常数(在I型中)和氧浓度(在II型中)。较低的光强度(I0)和较高的PS浓度(C0)提供了更高的功效,但对细胞的毒性也更大。较高的光强度(I0)可以加速交联,但具有较低的功效(对于相同剂量)。因此,C0/I0的最佳比例是加速和安全交联所必需的。除了PS浓度的限制外,安全性问题还限制了胶原蛋白的最大剂量。提出了三个重要问题:提高交联速度(通过更高的光强度)和交联效果,以及光敏剂(光引发剂)浓度的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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