Trypanosoma evansi: A Qualitative and Quantitative Ultrastructural Analysis of the Spleen during Experimental Murine Infections

L. P. d’Empaire, F. Tejero, H. Finol, P. Aso, A. Roschman-González
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Abstract

A murine model is used to study qualitatively and quantitatively the splenic ultrastructural changes induced by two Trypanosoma evansi strains derived from naturally infected local equine hosts (Equusasinus and E. caballus); T. evansi causes ultrastructural modifications in the spleen of the infected mice. The modifications include tissular disorganization, fibrosis, mitochondrial swelling, apoptosis and necrosis. The initial phases of the infection are quite similar, whereas the final phases differ qualitatively depending on the strain’s source. The ultrastructural quantitative changes were studied in the reticular splenocytes covering alterations in the area of the cytoplasm and nucleus. Analysis of the results shows the induction of various splenic alterations caused by local T. evansi strains. Also, it was documented that discriminative time modulation, as well as progressive tissular, cellular and subcellular changes, are more associated with derived infections from E. caballus strain.
伊氏锥虫实验性感染小鼠脾脏超微结构的定性和定量分析
使用小鼠模型定性和定量地研究了来源于自然感染的本地马宿主的两种伊氏锥虫菌株(Equsasinus和E.caballus)诱导的脾脏超微结构变化;埃文氏T.evansi引起受感染小鼠脾脏超微结构的改变。修饰包括组织紊乱、纤维化、线粒体肿胀、细胞凋亡和坏死。感染的最初阶段非常相似,而最终阶段根据菌株的来源而有质的不同。研究了网状脾细胞的超微结构定量变化,包括细胞质和细胞核区域的变化。对结果的分析表明,由埃文氏T.evansi局部菌株引起的各种脾脏改变的诱导作用。此外,有文献表明,辨别性时间调节以及进行性组织、细胞和亚细胞变化与E.caballus菌株的衍生感染更为相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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