Changes in the human placental transcriptome during the physiological course of pregnancy

Abstract

Аim . To determine the chan ges of gene expression in human placenta during the physiological course of pregnancy. Methods the integrative analysis of publicly available data. Results. We have revealed that between the first and second trimesters of gestation the main changes relate to immune processes, morphogenesis and intercellular communication through the surface receptors of the cellular membrane. In the interval between the second and third trimesters, the main changes concern the regulation of the response to external stimuli, metabolic processes, morphogenesis of individual tissues, regulation of signaling pathways via transmembrane serine / threonine protein kinase receptors. Conclusion. The changes in gene expression in human placenta in the course of physiological gestation will serve as a reliable control with the changes during the pathological course of gestation.