Evaluation of hematological and biochemical activity of Bauhinia strychnifolia Craib leaves ethanol extracts in normal albino rats

Abstract

The aim of this research is to evaluate the hematological and biochemical activity of Bauhinia strychnifolia Craib leaf ethanol extracts in normal albino rats. Thirty-two male and female rats were divided into four groups, each with equal numbers of male (n=4), female (n=4). The control group was administered 1 ml of 10% tween 80. The experimental groups were administered ethanol with concentrations of 125, 250 and 500 mg/kg body weight (bw). After 21 days of treatment, the blood samples were collected for hematological: Red blood cell (RBC), hemoglobin (HGB), hematocrit (HCT), mean corpuscular volume (MCV), white blood cell (WBC), neutrophil (NEU), lymphocyte (LYMPH), monocyte (MONO), eosinophil (EO), basophil (BASO) and biochemical analysis; glucose (GLU), blood urea nitrogen (BUN), creatinine (CREA), cholesterol (CHOL), and triglyceride (TG). The results showed that both male and female rats that received 500 mg/kg bw Craib leaf ethanol extract have increased RBC, HGB, HCT and WBC. The hematological activity in male rats increased significantly (p<0.05) compared to the control group. The biochemical activity in male rats administered with 125 mg/kg bw significantly (p < 0.05) increased BUN, CHOL, and TG compared to the control group. No evidence of abnormalities was observed. Key words: Bauhinia strychnifolia Craib, hematological, biochemical.