Characterization and in vitro Biocompatibility of Binary Mixtures of Chitosan and Polyurethanes Synthesized from Chemically Modified Castor Oil, as Materials for Medical Use

Q2 Materials Science

Polymers from Renewable Resources Pub Date : 2018-09-04 DOI:10.1177/204124791800900102

Fabián R. Arévalo, Sonia A. Osorio, Nathaly A. Valcárcel, Jeimmy C. Ibarra, M. Valero

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引用次数: 6

Abstract

This study aimed to evaluate the effect of the incorporation of chitosan into polyurethane matrices synthesized from chemically modified castor (Ricinus communis) oil by transesterification with pentaerythritol. An additional aim of this study was to determine the degree of acceptance as a biomaterial (obtained from renewable sources), based on the analysis of its mechanical properties (stress/rupture strain), hydrophilic character (contact angle), morphology (SEM) and in vitro compatibility of polyurethanes when in contact with mouse fibroblast L929 cells. No significant changes in mechanical properties were observed with the addition of chitosan to polyurethanes synthesized from chemically modified castor oil. All polyurethane formulas showed morphological changes with increased chitosan concentration. As chitosan/polyurethane binary mixtures do not present a cytotoxicity risk for L929 mouse fibroblasts and possess similar mechanical properties to soft and cardiovascular tissues, their use as a biomedical material is suggested.

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由化学改性蓖麻油合成的壳聚糖和聚氨酯二元混合物作为医用材料的表征和体外生物相容性

本研究旨在评估壳聚糖掺入由化学改性蓖麻油与季戊四醇酯交换合成的聚氨酯基质中的效果。本研究的另一个目的是基于对聚氨酯与小鼠成纤维细胞L929细胞接触时的机械性能（应力/断裂应变）、亲水性（接触角）、形态（SEM）和体外相容性的分析，确定其作为生物材料（从可再生来源获得）的接受程度。在化学改性蓖麻油合成的聚氨酯中加入壳聚糖后，力学性能没有显著变化。随着壳聚糖浓度的增加，所有聚氨酯配方都表现出形态变化。由于壳聚糖/聚氨酯二元混合物对L929小鼠成纤维细胞没有细胞毒性风险，并且具有与软组织和心血管组织相似的机械性能，因此建议将其用作生物医学材料。

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来源期刊

Polymers from Renewable Resources Materials Science-Polymers and Plastics

CiteScore

3.50

自引率

0.00%

发文量

期刊介绍： Polymers from Renewable Resources, launched in 2010, publishes leading peer reviewed research that is focused on the development of renewable polymers and their application in the production of industrial, consumer, and medical products. The progressive decline of fossil resources, together with the ongoing increases in oil prices, has initiated an increase in the search for alternatives based on renewable resources for the production of energy. The prevalence of petroleum and carbon based chemistry for the production of organic chemical goods has generated a variety of initiatives aimed at replacing fossil sources with renewable counterparts. In particular, major efforts are being conducted in polymer science and technology to prepare macromolecular materials based on renewable resources. Also gaining momentum is the utilisation of vegetable biomass either by the separation of its components and their development or after suitable chemical modification. This journal is a valuable addition to academic, research and industrial libraries, research institutions dealing with the use of natural resources and materials science and industrial laboratories concerned with polymer science.