Mesua ferrea L. (Calophyllaceae) exerts therapeutic effects in allergic asthma by modulating cytokines production in asthmatic rats

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2021-12-31 DOI:10.3906/bot-2111-22

Poonam Arora

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引用次数: 4

Abstract

: In the present study, ethanolic extract of Mesua ferrea L. stamens was investigated for its potential to reverse some features of bronchial asthma in ovalbumin-induced murine model of asthma. Mesua ferrea commonly called nagakeshar (Family, Calophyllaceae) is a well-known antiallergic drug in the Asian folk system of medicines. In the present work, pharmacological studies are done to provide scientific evidence for therapeutic potential of plants in allergic asthma. Asthma was induced in experimental rats with allergen suspension of ovalbumin and aluminium hydroxide followed by treatment with dexamethasone (2.5 mg/kg, p.o) or M. ferrea stamen extract (3.75 and 15 mg/kg, b.w., p.o). Biomarkers of inflammatory response including cell counts, Immunoglobulin E, cytokines such as interleukin (IL)-4, -5, -1 β , tumor necrosis factor (TNF)- α , leukotriene (LT)-D-4, and nitrite concentration in blood as well as bronchial (BAL) fluid were tested. Lung functions in asthmatic and treated animals were evaluated as breathing rate and tidal volume. Treatment with M. ferrea stamen extract (MFE) markedly (p < 0.001, p < 0.01 and p < 0.05) diminished infiltration of inflammatory cells, IgE, cytokines, and nitrites in blood/serum and bronchial fluid. Improvement in lung functions (p < 0.05) of asthmatic animals after MFE treatment also supports our findings. Results of the study suggest a therapeutic potential of M. ferrea in allergic asthma that can be related to the ability of plants to attenuate the response of inflammatory cells and thereby, the production of inflammatory and proinflammatory cytokines in airways.

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铁藻通过调节哮喘大鼠细胞因子的产生对过敏性哮喘的治疗作用

在本研究中，在卵清蛋白诱导的哮喘小鼠模型中，研究了铁花雄蕊的乙醇提取物逆转支气管哮喘某些特征的潜力。铁藻（Mesua ferrea）通常被称为nagakeshar（海藻科），是亚洲民间药物体系中一种著名的抗过敏药物。在本工作中，进行了药理学研究，为植物治疗过敏性哮喘的潜力提供了科学证据。用卵清蛋白和氢氧化铝的过敏原悬浮液诱导实验大鼠哮喘，然后用地塞米松（2.5 mg/kg，p.o）或铁藻雄蕊提取物（3.75和15 mg/kg，b.w.，p.o，检测血液和支气管（BAL）液中的亚硝酸盐浓度、白三烯（LT）-D-4和亚硝酸盐浓度。哮喘动物和治疗动物的肺功能评估为呼吸频率和潮气量。铁藻雄蕊提取物（MFE）治疗显著（p＜0.001、p＜0.01和p＜0.05）减少了血液/血清和支气管液中炎症细胞、IgE、细胞因子和亚硝酸盐的浸润。MFE治疗后哮喘动物肺功能的改善（p<0.05）也支持我们的研究结果。研究结果表明，铁藻在过敏性哮喘中具有治疗潜力，这可能与植物减弱炎症细胞反应的能力有关，从而减少气道中炎症和促炎细胞因子的产生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.