Effects of vitamin D3 supplementation combined with standardized hypoglycemic regimen on islet β cell function and macrovascular complications in newly diagnosed type 2 diabetes mellitus

Q4 Nursing

中华临床营养杂志 Pub Date : 2019-12-30 DOI:10.3760/CMA.J.ISSN.1674-635X.2019.06.005

Shiwei Liu, Ruixue Duan, Xin Li, Jiaxin Zhang, Yaru Wu

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Abstract

Objective To investigate the effects of vitamin D3 supplementation combined with standardized hypoglycemic regimen on islet β cell function and macroangiopathy of T2DM patients. Methods A total of 192 patients with type 2 diabetes mellitus were selected and randomly divided into control group and observation group with 96 patients in each group. Patients in two groups were given standardized hypoglycemic regimen, and the observation group was treated with vitamin D3 supplementation in addition. The changes of the indexes of body examination, glycolipid metabolism, islet β cell function and macrovascular complications before and 6 months after treatment were compared between the two groups. Results After 6 months of treatment, BMI, SBP, TG, FBG, FINS, HbA1c and HOMA-IR decreased, while HOMA-β increased in both groups (P<0.05). Compared with the control group, the serum levels of 25 (OH) D increased, and vaspin and CRP decreased significantly after 6 months of treatment in the observation group (P<0.05). CIMT and other indicators showed no significant difference. 25 (OH) D was negatively correlated with FBG, FINS, vaspin and CRP, and positively correlated with 1PH and ISI (P<0.05). Conclusion Vitamin D3 is closely related to T2DM and its macrovascular complications, but it has not been found that vitamin D3 supplementation can further improve islet β cell function and macrovascular complications in patients with T2DM. Key words: Type 2 diabetes; Vitamin D; Islet Cell Function; Macroangiopathy; Vaspin

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补充维生素D3联合标准化降糖方案对新诊断2型糖尿病胰岛β细胞功能及大血管并发症的影响

目的探讨补充维生素D3联合标准化降糖方案对2型糖尿病患者胰岛β细胞功能及大血管病变的影响。方法选择192例2型糖尿病患者，随机分为对照组和观察组，每组96例。两组患者均给予标准化降糖方案，观察组补充维生素D3治疗。比较两组治疗前后身体检查、糖脂代谢、胰岛β细胞功能及大血管并发症等指标的变化。结果治疗6个月后，两组患者的BMI、SBP、TG、FBG、FINS、HbA1c和HOMA-IR均下降，HOMA-β升高（P<0.05）。与对照组相比，观察组治疗6个月后血清25（OH）D水平升高，vaspin和CRP显著下降（P<0.05），CIMT等指标无显著差异。25（OH）D与FBG、FINS、vaspin和CRP呈负相关，与1PH和ISI呈正相关（P<0.05）。结论维生素D3与T2DM及其大血管并发症密切相关，但尚未发现补充维生素D3能进一步改善T2DM患者胰岛β细胞功能和大血管并发症。关键词：2型糖尿病；维生素D；胰岛细胞功能；大血管病；瓦斯平

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来源期刊

中华临床营养杂志 Nursing-Nutrition and Dietetics

CiteScore

0.20

自引率

0.00%

发文量

2282

期刊介绍： The Chinese Journal of Clinical Nutrition was founded in 1993. It is the first professional academic journal (bimonthly) in my country co-sponsored by the Chinese Medical Association and the Chinese Academy of Medical Sciences to disseminate information on clinical nutrition support, nutrient metabolism, the impact of nutrition support on outcomes and "cost-effectiveness", as well as translational medicine and nutrition research. It is also a professional journal of the Chinese Medical Association's Parenteral and Enteral Nutrition Branch. The purpose of the Chinese Journal of Clinical Nutrition is to promote the rapid dissemination of knowledge on nutrient metabolism and the rational application of parenteral and enteral nutrition, focusing on the combination of multidisciplinary and multi-regional field investigations and clinical research. It mainly reports on nutritional risk screening related to the indications of parenteral and enteral nutrition support, "cost-effectiveness" research on nutritional drugs, consensus on clinical nutrition, guidelines, expert reviews, randomized controlled studies, cohort studies, glycoprotein and other nutrient metabolism research, systematic evaluation of clinical research, evidence-based case reports, special reviews, case reports and clinical experience exchanges, etc., and has a special column on new technologies related to the field of clinical nutrition and their clinical applications.