Polymorphism in STAT4 Increase the Risk of Systemic Lupus Erythematosus: An Updated Meta-Analysis

IF 2.3 Q2 RHEUMATOLOGY
Shancui-zheng, Jinping-Zhang, Guoyuan-lu, Lei Liu, Zhiyong-deng
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引用次数: 1

Abstract

Previous studies have reported that STAT4 rs7574865 conferred the susceptibility to systemic lupus erythematosus (SLE). In this study, a meta-analysis (including 32 comparative studies of 11384 patients and 17609 controls) was conducted to investigate the role of STAT4 polymorphism in SLE in a comprehensive way. We found that the Asian population had the highest prevalence of the T allele than any other study population at 32.2% and that STAT4 rs7574865 polymorphism was associated with SLE in the overall population (OR = 1.579, 95%CI = 1.497-1.665, P < 0.001). In the subgroup analysis by ethnicity, STAT4 rs7574865 T allele was shown to be risk factor in SLE in Asian, European, and American origins. Our results do support STAT4 rs7574865 polymorphism as a susceptibility factor for SLE in populations of different ethnic and that its prevalence is ethnicity dependent.
STAT4基因多态性增加系统性红斑狼疮发病风险的最新Meta分析
先前的研究报道STAT4 rs7574865赋予系统性红斑狼疮(SLE)易感性。在本研究中,进行了一项荟萃分析(包括11384名患者和17609名对照的32项比较研究),以全面研究STAT4多态性在SLE中的作用。我们发现,亚洲人群的T等位基因患病率最高,为32.2%,STAT4 rs7574865多态性与整个人群的SLE相关(OR=1.579,95%CI=1.97-1.665,P<0.001)。我们的研究结果确实支持STAT4 rs7574865多态性作为不同种族人群SLE的易感因素,并且其患病率是种族依赖性的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.40
自引率
0.00%
发文量
9
审稿时长
24 weeks
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