Relationship between Salivary Levels of Protein Carbonyl and Total Antioxidant Capacity and Prevalence of Dental Caries among Type 1 Diabetic Children: An Analytical Cross-Sectional Study

IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Dental Hypotheses Pub Date : 2023-04-01 DOI:10.4103/denthyp.denthyp_44_23

Shahad Obaid, Shahba'a Munther, Marwa Abbas

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Abstract

Introduction: We aimed to assess the possible relationship between dental caries prevalence and oxidative stress markers such as protein carbonyl (PC) and total antioxidant capacity (TAOC) of saliva among type 1 diabetic children. Methods: An analytical cross-sectional study was performed among 45 type 1 diabetic children and compared with 45 healthy control children aged 10 to 12 years old. Dental caries was diagnosed and recorded using the decayed, missing, and filling index (DMFS/dmfs). Unstimulated salivary specimens were collected for evaluation of TAOC and PC using an enzyme-linked immune-sorbent assay (ELISA). A linear regression model and one-way ANOVA test were employed for data analysis using the R 4.3.0. Results: Salivary levels of TAOC and PC, having diabetes, and diabetes status (controlled or uncontrolled) were not statistically significant (P > 0.05) predicators regarding the prevalence of dental caries among type 1diabetic children. Conclusion: The diabetic status had a significant effect on salivary levels of TAOC and PC, but no significant effect on the prevalence of dental caries.

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唾液蛋白质羰基水平与1型糖尿病儿童总抗氧化能力和龋齿患病率的关系：一项横断面分析研究

引言：我们旨在评估1型糖尿病儿童的龋齿患病率与氧化应激标志物（如蛋白质羰基（PC）和唾液总抗氧化能力（TAOC））之间的可能关系。方法：对45名1型糖尿病儿童进行横断面分析研究，并与45名10至12岁的健康对照儿童进行比较。使用龋齿、缺失和填充指数（DMFS/DMFS）对龋齿进行诊断和记录。收集未刺激的唾液样本，使用酶联免疫吸附测定法（ELISA）评估TAOC和PC。采用线性回归模型和单因素方差分析检验，使用R 4.3.0进行数据分析。结果：唾液中TAOC和PC水平、患有糖尿病和糖尿病状态（控制或未控制）对1型糖尿病儿童龋齿患病率没有统计学意义（P>0.05）。结论：糖尿病状态对唾液TAOC和PC水平有显著影响，但对龋齿患病率无显著影响。

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