SHORT PEPTIDE-BASED POLYSACCHARIDE HYDROGELS FOR TISSUE ENGINEERING: A MINI REVIEW

Abstract

The usage of short peptide-based polysaccharide hydrogels for tissue engineering was discussed in this review. It explained the drawbacks of employing short peptide-based polysaccharide hydrogels as tissue regeneration scaffolds, while highlighting their benefits. In this review, we first gave a brief overview of short peptide-based polysaccharide hydrogel design process. Then, we provided additionally detailed information of the hydrogels with categorized polysaccharides (hyaluronic acid, dextran, chitosan, alginate, and agarose). We also explained the bioactive short peptides Arg-Gly-Asp (RGD), Ile-Lys-Val-Ala-Val (IKVAV), and Tyr-Ile-Gly-Ser-Arg (YIGSR) that were used to modify these polysaccharide hydrogels in order to enhance cell behaviors, including survival, adhesion, proliferation, and migration. Their applications in tissue engineering were also demonstrated and summarized in this review.