A Computational Approach for Stent Elution Rate Determined Specific Drug Binding and Receptor-mediated Effects in Arterial Tissue

Abstract

In the present article the effects of drug binding (both specific and nonspecific) in the porous arterial wall following stent-based drug delivery from drug-eluting stents (DESs) are investigated. A three-phase (free, extracellular matrix-bound, and specific receptor-bound) second-order nonlinear saturable reversible binding model is considered in order to describe the binding process with the constituents of the porous arterial wall. Although, there are currently some precise forms of a drug binding model in the arterial tissue in the literature, analyzed by various authors. The specific interest in this present context is in assessing to what extent modelling of specific and nonspecific binding within a single-layered homogeneous porous arterial wall is possible. A novel axi-symmetric model of drug delivery from three stent struts has been developed and is presented.