Characterization of Neuropathic Pain in Sickle Cell Disease

IF 0.2 4区医学 Q4 MEDICINE, GENERAL & INTERNAL

West Indian Medical Journal Pub Date : 2017-10-26 DOI:10.7727/WIMJOPEN.2017.164

M. Nalbandian, H. Kyotakoze, H. Kaminsky, D. Keleny, P. Baghdasaryan, A. McDonald, T. Erwes, T. Mylläri, K. Nalbandyan, T. Jalonen

{"title":"Characterization of Neuropathic Pain in Sickle Cell Disease","authors":"M. Nalbandian, H. Kyotakoze, H. Kaminsky, D. Keleny, P. Baghdasaryan, A. McDonald, T. Erwes, T. Mylläri, K. Nalbandyan, T. Jalonen","doi":"10.7727/WIMJOPEN.2017.164","DOIUrl":null,"url":null,"abstract":"Objective: Sickle cell disease (SCD) is a multifaceted, chronic disease that severely affects the quality of life of patients globally. Recurrent episodes of pain are a hallmark of SCD; however, there are limited data on the characterization of the pain. This paper characterizes the types of pain experienced by persons living with SCD in Grenada, West Indies. More specifically, it assesses the presence of neuropathic pain in these individuals. This study hopes to increase awareness of the types of pain in SCD and contribute to the development of effective pain management guidelines. Methods: A cross-sectional study was performed to assess the presence and characteristics of pain in patients with a confirmed diagnosis of SCD in Grenada. Participants were selected randomly from the registry provided by the Sickle Cell Association of Grenada. The painDETECT questionnaire was used to provide quantitative data and the McGill-Melzack Pain Questionnaire to provide qualitative data. Results: The study examined 63 participants, 24 males and 39 females, with a mean age of 21.16 years. In the McGill-Melzack Pain Questionnaire, participants chose pain descriptors for all three types of pain: nociceptive, affective/evaluative and neuropathic. An independent sample median test found neuropathic pain descriptors to be significantly different across age groups (p = 0.046). There was no age dependency in nociceptive and affective/evaluative pain. The mean final score of all participants in the painDETECT survey was 19.27 (95% CI: 17.25, 21.29), which is a score suggestive of a neuropathic pain component. There was also a positive correlation of 0.41 (p = 0.01) between age and painDETECT final score. Furthermore, a positive correlation of 0.56 (p < 0.001) existed between the number of neuropathic pain descriptors chosen and the painDETECT final score. Conclusion: The presence of all three types of pain, as well as the presence of neuropathic pain with increasing age, indicates the need for a multimodal pain management plan that is individually targeted and varied throughout the life of a patient with SCD.","PeriodicalId":49366,"journal":{"name":"West Indian Medical Journal","volume":"4 1","pages":"17-23"},"PeriodicalIF":0.2000,"publicationDate":"2017-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"West Indian Medical Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.7727/WIMJOPEN.2017.164","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}

引用次数: 5

Abstract

Objective: Sickle cell disease (SCD) is a multifaceted, chronic disease that severely affects the quality of life of patients globally. Recurrent episodes of pain are a hallmark of SCD; however, there are limited data on the characterization of the pain. This paper characterizes the types of pain experienced by persons living with SCD in Grenada, West Indies. More specifically, it assesses the presence of neuropathic pain in these individuals. This study hopes to increase awareness of the types of pain in SCD and contribute to the development of effective pain management guidelines. Methods: A cross-sectional study was performed to assess the presence and characteristics of pain in patients with a confirmed diagnosis of SCD in Grenada. Participants were selected randomly from the registry provided by the Sickle Cell Association of Grenada. The painDETECT questionnaire was used to provide quantitative data and the McGill-Melzack Pain Questionnaire to provide qualitative data. Results: The study examined 63 participants, 24 males and 39 females, with a mean age of 21.16 years. In the McGill-Melzack Pain Questionnaire, participants chose pain descriptors for all three types of pain: nociceptive, affective/evaluative and neuropathic. An independent sample median test found neuropathic pain descriptors to be significantly different across age groups (p = 0.046). There was no age dependency in nociceptive and affective/evaluative pain. The mean final score of all participants in the painDETECT survey was 19.27 (95% CI: 17.25, 21.29), which is a score suggestive of a neuropathic pain component. There was also a positive correlation of 0.41 (p = 0.01) between age and painDETECT final score. Furthermore, a positive correlation of 0.56 (p < 0.001) existed between the number of neuropathic pain descriptors chosen and the painDETECT final score. Conclusion: The presence of all three types of pain, as well as the presence of neuropathic pain with increasing age, indicates the need for a multimodal pain management plan that is individually targeted and varied throughout the life of a patient with SCD.

查看原文本刊更多论文

镰状细胞病的神经性疼痛特征

目的：镰状细胞病（SCD）是一种多方面的慢性疾病，严重影响全球患者的生活质量。反复发作的疼痛是SCD的标志；然而，关于疼痛特征的数据有限。本文描述了西印度群岛格林纳达SCD患者所经历的疼痛类型。更具体地说，它评估了这些人是否存在神经性疼痛。这项研究希望提高人们对SCD疼痛类型的认识，并有助于制定有效的疼痛管理指南。方法：对格林纳达确诊为SCD的患者进行横断面研究，以评估其疼痛的存在和特征。参与者是从格林纳达镰状细胞协会提供的登记册中随机选择的。painDETECT问卷用于提供定量数据，McGill-Melzack疼痛问卷用于提供定性数据。结果：该研究调查了63名参与者，其中24名男性和39名女性，平均年龄21.16岁。在麦吉尔-梅尔扎克疼痛问卷中，参与者为所有三种类型的疼痛选择了疼痛描述符：伤害性疼痛、情感性疼痛/评估性疼痛和神经性疼痛。一项独立样本中位数测试发现，不同年龄组的神经性疼痛描述符存在显著差异（p=0.046）。伤害性疼痛和情感性/评估性疼痛没有年龄依赖性。painDETECT调查中所有参与者的平均最终得分为19.27（95%置信区间：17.25，21.29），这是一个提示神经性疼痛成分的得分。年龄和painDETECT最终评分之间也存在0.41（p=0.01）的正相关。此外，所选择的神经病理性疼痛描述符的数量与painDETECT最终评分之间存在0.56的正相关（p＜0.001）。结论：所有三种类型的疼痛的存在，以及随着年龄的增长而出现的神经性疼痛，表明需要一种多模式的疼痛管理计划，该计划在SCD患者的一生中具有针对性和多样性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

West Indian Medical Journal 医学-医学：内科

CiteScore

0.20

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： The Journal is international in scope, with author and editorial contributions from across the globe. The focus is on clinical and epidemiological aspects of tropical and infectious diseases, new and re-emerging infections, chronic non-communicable diseases, and medical conditions prevalent in the Latin America-Caribbean region, and of significance to global health, especially in developing countries. The Journal covers all medical disciplines, as well as basic and translational research elucidating the pathophysiologic basis of diseases or focussing on new therapeutic approaches, and publishes original scientific research, reviews, case reports, brief communications, letters, commentaries and medical images. The Journal publishes four to six issues and four supplements annually. English is the language of publication but Abstracts are also duplicated in Spanish. Most of the articles are submitted at the authors’ initiative, but some are solicited by the Editor-in-Chief. Unless expressly stated, the Editorial Board does not accept responsibility for authors’ opinions. All papers on submission are reviewed by a subcommittee. Those deemed worthy for review are sent to two or three reviewers (one of the three might be a statistician if necessary). The returned papers with reviewer comments are reviewed by the Editor-in-Chief. Papers may be rejected, accepted or sent back to authors for revision. Resubmitted papers from authors are reviewed by the Editor-in-Chief and may be sent back to reviewers or a final decision made by Editor-in-Chief. The decision of the Editorial Board is final with regards to rejected articles. Rejected articles will not be returned to the authors. The editorial subcommittee has the right to return sub-standard manuscripts to the authors, rather than passing them on to the reviewers. This implies outright rejection of the manuscript.