Ameliorative Synergistic Effect of Honey and MO on Lead-Induced Alteration of Biochemical and Haematological Indices in Clarias gariepinus

T. Ayandiran, A. Akintola, B. Kehinde, Ogundola Adijat, Fawole O. Olatunde, A. B. Peter, Akitunde Akinniyi, Folorunso Kolade
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Abstract

Lead confers deleterious damage to the cells and it is necessary to explore further and develop a more effective way to ameliorate lead toxicity. This study aims to investigate how honey and Moringa oleifera (MO) can synergistically provide a more effective way to ameliorate lead toxicity. Groups of ten fish (Clarias gariepinus) were given Pb (0.30 g) and supplemented feed (T1) containing both honey (5 g) and MO (5 g). Others received pb (0.30 g) and supplemented feed (T2) containing either honey (10 g) or (T3) containing MO (10 g). Finally, hematological and biochemical analysis were conducted and a decline in the hematological parameters was observed. Also, the level of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), urea, creatinine, and malondialdehyde (MDA) significantly increased while glutathione (GSH) and superoxide dismutase (SOD) reduced in the group given lead only. However, these biochemical indices and hematological parameters are greatly restored in the group that received both honey and MO compared to the group that received either honey or MO. The findings of this study reveal that co-administration of both honey and MO synergistically damages caused by lead-induced toxicity better.
蜂蜜和MO对铅诱导的加里皮Clarias生化和血液学指标变化的增效作用
铅对细胞造成有害损害,有必要进一步探索和开发一种更有效的方法来改善铅毒性。本研究旨在探讨蜂蜜和辣木(MO)如何协同提供一种更有效的方法来改善铅毒性。给10条鱼(Clarias gariepinus)一组喂食Pb(0.30克)和含有蜂蜜(5克)和MO(5 g)的补充饲料(T1)。其他人接受铅(0.30克)和补充饲料(T2),其中含有蜂蜜(10克)或(T3),含有MO(10 g)。最后,进行血液学和生化分析,观察到血液学参数下降。此外,在仅给予铅的组中,丙氨酸氨基转移酶(ALT)、天冬氨酸转氨酶(AST)、碱性磷酸酶(ALP)、尿素、肌酸酐和丙二醛(MDA)水平显著升高,而谷胱甘肽(GSH)和超氧化物歧化酶(SOD)水平降低。然而,与接受蜂蜜或MO的组相比,同时接受蜂蜜和MO的组的这些生化指标和血液学参数大大恢复。本研究的结果表明,蜂蜜和MO联合给药对铅诱导的毒性造成的协同损害更好。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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