Evaluation of diagnostic value of laboratory tests (CRP, WBC and ESR) in patients with COVID-19 in Shahid Sadoughi Hospital, Yazd

Abstract

COVID-19 disease is spreading rapidly around the world and its control requires proper diagnosis of infected people. RTPCR is the primary method of laboratory diagnosis of COVID-19, but is associated with false-positive cases. Therefore, the aim of this study was to evaluate the diagnostic value of laboratory tests (CRP, WBC and ESR) in the diagnosis of COVID-19. In a cross-sectional and descriptive-analytical study, the file of 200 patients with COVID-19 admitted to Shahid Sadoughi Hospital in Yazd in 2020-2021was evaluated and the results of laboratory tests (CRP, WBC and ESR) were recorded. Considering RT-PCR and lung CT scan as the gold standard, the sensitivity and specificity of each test were determined. Data were analyzed using SPSS software. The frequency of positive findings of CT scan, RT-PCR and gold standard in the studied patients were 83.5%, 50% and 91%, respectively. The mean WBC of patients was 109 2.17 and the ESR was 43.79 mm / h. CRP test was also positive in 71.3% of patients. The sensitivity and specificity of WBC, ESR and CRP in the detection of COVID-19 were 31.5%, 62.4% and 73.1%, respectively, and their specificity was 63.6%, 22.2% and 42.1%, respectively. The frequency of CRP, WBC and ESR findings was not significantly different from the gold standard findings in the studied patients (P> 0.05). CRP test is more sensitive than ESR and WBC in diagnosing COVID-19 and can be used in screening patients.