Design and Experiment Research of a Novel Retrievable Peripheral Vascular Stent

IF 0.8 4区 医学 Q4 ENGINEERING, BIOMEDICAL
Jingzhen Guo, L. Mao, Chengli Song, Yiling Shi, Yongji Tian
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引用次数: 0

Abstract

Restenosis after stent implantation is a major limitation of revascularization technique. Retrieving the stent safely and smoothly after the vascular remodeling is completed shows important clinical significance. In this paper, a novel retrievable peripheral vascular stent and its modified retrieval platform were developed and the finite element analysis (FEA) model was established to study the retrieval process of the stent. Meanwhile, the safety and feasibility of the retrievable stent were assessed through in vivo experiments. The maximum strain of the stent is 6.87% during the whole retrieval process, which is less than the ultimate elastic strain of nitinol alloy. The simulation results indicate that the stent is not damaged or stuck during the whole retrieval process. Finally, the stents were implanted into Bama miniature pigs to assess the retrieval process, and the results suggest that the stents can be retrieved successfully within a short period of time after implantation, and minor local mechanical injury can be found in the intimal layer of the blood vessel due to the expansion and contraction of the stent. Studies presented in this work illustrate the feasibility of a novel retrievable peripheral vascular stent, providing an additional avenue to avoid in-stent restenosis.
一种新型可回收外周血管支架的设计与实验研究
支架植入后再狭窄是血运重建技术的主要局限性。血管重建完成后安全、顺利地取出支架具有重要的临床意义。本文开发了一种新型的可回收外周血管支架及其改进的回收平台,并建立了有限元分析模型来研究支架的回收过程。同时,通过体内实验评估了可回收支架的安全性和可行性。支架在整个取出过程中的最大应变为6.87%,小于镍钛合金的极限弹性应变。仿真结果表明,支架在整个取出过程中没有损坏或卡住。最后,将支架植入巴马小型猪体内,以评估支架的取出过程,结果表明,支架可以在植入后的短时间内成功取出,并且由于支架的膨胀和收缩,可以在血管内膜层发现轻微的局部机械损伤。这项工作中的研究表明了一种新型可回收外周血管支架的可行性,为避免支架内再狭窄提供了额外的途径。
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来源期刊
CiteScore
1.80
自引率
11.10%
发文量
56
审稿时长
6-12 weeks
期刊介绍: The Journal of Medical Devices presents papers on medical devices that improve diagnostic, interventional and therapeutic treatments focusing on applied research and the development of new medical devices or instrumentation. It provides special coverage of novel devices that allow new surgical strategies, new methods of drug delivery, or possible reductions in the complexity, cost, or adverse results of health care. The Design Innovation category features papers focusing on novel devices, including papers with limited clinical or engineering results. The Medical Device News section provides coverage of advances, trends, and events.
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