Maternal breast feeding safety of hepatitis B virus carrying parturient women with hepatitis B surface antigen and hepatitis B e antigen double positive

中华传染病杂志 Pub Date : 2020-01-15 DOI:10.3760/CMA.J.ISSN.1000-6680.2020.01.006

Hong Wang, Hongping Wang, Linyan Qian, Lingyan Xu

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引用次数: 1

Abstract

Objective To explore hepatitis B virus (HBV) infection rate of breast feeding to newborn babies of HBV carrying parturient women with hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) double positive. Methods A prospective cohort study was conducted to include HBsAg and HBeAg double-positive HBV carrying parturient women and their babies born from February 2016 to May 2018 at the Women′s Hospital, Zhejiang University School of Medicine, and 323 parturient women and 323 babies were enrolled. The babies were divided into breast feeding group and artificial feeding group. Chemiluminescence immunoassay and polymerase chain reaction-fluorescent probe method were used to detect the positive rates of serum HBV markers and HBV DNA levels in the newborns <24 h and seven-month-old age, respectively. The statistical method was performed using χ2 test. Results A total of 297 parturient women were finally included for the analysis, including 149 in the breast feeding group and 148 in the artificial feeding group. There were no significant differences in the positive rates of HBsAg, hepatitis B surface antibody (anti-HBs), HBeAg and HBV DNA>100 IU/mL between the two groups at birth 0.05). The positive rate of anti-HBs in newborns in the breast feeding group at birth 100 IU/mL in newborns in the breast feeding group were 2.01%(3/149) and 2.68%(4/149) at birth 0.05). In the artificial feeding group, the positive rate of anti-HBs in newborns was 47.97%(71/148) at birth 100 IU/mL in newborns in the artificial feeding group at birth 0.05). Conclusions Breast feeding is not a decisive factor for the risk of vertical transmission in HBsAg and HBeAg double-positive HBV carriers. It is recommended that such women could breastfeed under formal precautions. Key words: Hepatitis B; Breast feeding; Mother-to-child transmission

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乙型肝炎表面抗原和乙型肝炎e抗原双阳性产妇的母乳喂养安全性

目的探讨乙型肝炎表面抗原（HBsAg）和乙型肝炎e抗原（HBeAg）双阳性产妇母乳喂养新生儿的乙型肝炎病毒（HBV）感染率。方法对浙江大学医学院妇女医院2016年2月至2018年5月出生的携带HBsAg和HBeAg双阳性HBV的产妇及其婴儿进行前瞻性队列研究，纳入323名产妇和323名婴儿。将婴儿分为母乳喂养组和人工喂养组。采用化学发光免疫法和聚合酶链式反应荧光探针法检测两组新生儿血清HBV标志物和HBVDNA的阳性率（出生时100IU/mL，0.05），母乳喂养组新生儿抗-HBs的阳性率分别为2.01%（3/149）和2.68%（4/149）人工喂养组新生儿抗-HBs阳性率为47.97%（71/148），人工喂养组为100IU/mL。结论母乳喂养不是HBsAg和HBeAg双阳性HBV携带者垂直传播风险的决定性因素。建议这些妇女在采取正式预防措施的情况下进行母乳喂养。关键词：乙型肝炎；母乳喂养；母婴传播

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来源期刊

中华传染病杂志

自引率

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发文量

5280

期刊介绍： The Chinese Journal of Infectious Diseases was founded in February 1983. It is an academic journal on infectious diseases supervised by the China Association for Science and Technology, sponsored by the Chinese Medical Association, and hosted by the Shanghai Medical Association. The journal targets infectious disease physicians as its main readers, taking into account physicians of other interdisciplinary disciplines, and timely reports on leading scientific research results and clinical diagnosis and treatment experience in the field of infectious diseases, as well as basic theoretical research that has a guiding role in the clinical practice of infectious diseases and is closely integrated with the actual clinical practice of infectious diseases. Columns include reviews (including editor-in-chief reviews), expert lectures, consensus and guidelines (including interpretations), monographs, short monographs, academic debates, epidemic news, international dynamics, case reports, reviews, lectures, meeting minutes, etc.