Gadoterate meglumine - anionic linear globular dendrimer second generation: A novel nano sized theranostic contrast agent

IF 1.4 Q4 NANOSCIENCE & NANOTECHNOLOGY
Noorin Yousefiyeh, Abolfazl Arab, Elnaz Salehian, R. Alikhani, Shabnam Samimi, A. Assadi, M. Ardestani
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引用次数: 2

Abstract

Objective(s): Cancer is known as one of the most life-threatening diseases in the world. Early diagnosis of cancer may significantly increase the chance of effective treatment. In the recent years, the importance of medical imaging usage has been increased to identify cancer’s nature and pattern of growth in order to provide the most advantageous treatment approaches for cancer tumors. Magnetic resonance imaging is an efficient non-invasive tool for early diagnosis of cancer which provides clear scans of various tissues without radiation. Contrast Agents such as Gadoterate Meglumine enhance contrast MR imaging and provide imaging from inside the cells without entering them.Materials and Methods: In this study, Gadoterate Meglumine nano-sized anionic linear globular dendrimer second generation was first synthesized and then qualitative and quantitative methods were carried out to ensure the proper synthesis and to assess the toxicity of the compound. Once the non-toxicity of the chemical was ensured, in vivo MR imaging studies was performed to test the impact of the synthesized compound on the resolution of image. Results: The result obtained from this study demonstrated that the attachment of Gadolinium (III) to a nano dendrimer reduces its cytotoxicity and also improved resolution of image. In this research, Gadoterate Meglumine nano-sized anionic linear globular dendrimer second generation was effectively able to enter the cells while showing low cytotoxicity in the normal cells and moderate cytotoxicity on cancer cells. Conclusion: Therefore, ALGDG2-GM could be introduced as a novel, safe, effective and promising nano-sized theranostic contrast agent candidate.
Gadotrate葡胺-阴离子线性球状树枝状大分子第二代:一种新型纳米治疗造影剂
目的:癌症是世界上最致命的疾病之一。癌症的早期诊断可能会显著增加有效治疗的机会。近年来,医学成像应用的重要性已经增加,以确定癌症的性质和生长模式,从而为癌症肿瘤提供最有利的治疗方法。磁共振成像是癌症早期诊断的一种有效的非侵入性工具,它可以在没有辐射的情况下对各种组织进行清晰的扫描。造影剂如Gadoterate Meglumine增强了对比度MR成像,并在不进入细胞的情况下从细胞内部提供成像。材料与方法:本研究首先合成了Gadoterate Meglumine纳米阴离子线性球形树枝状大分子第二代,然后进行了定性和定量方法,以确保该化合物的正确合成并评估其毒性。一旦确保了该化学品的无毒性,就进行了体内MR成像研究,以测试合成化合物对图像分辨率的影响。结果:本研究结果表明,钆(III)与纳米树枝状大分子的结合降低了其细胞毒性,并提高了图像的分辨率。在本研究中,Gadoterate Meglumine纳米尺寸阴离子线性球形树枝状聚合物第二代能够有效地进入细胞,同时对正常细胞表现出较低的细胞毒性,对癌症细胞表现出中等的细胞毒性。结论:ALGDG2-GM是一种新型、安全、有效、有前景的纳米治疗造影剂。
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来源期刊
Nanomedicine Journal
Nanomedicine Journal NANOSCIENCE & NANOTECHNOLOGY-
CiteScore
3.40
自引率
0.00%
发文量
0
审稿时长
12 weeks
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