Chronic antidepressant use: Effects on various organ histology and blood cell counts in adult albino rats

IF 0.7 Q4 PHARMACOLOGY & PHARMACY
M. Bariweni, Y. Oboma, Ebibodo Samuel
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引用次数: 0

Abstract

Background: Chronic use of antidepressant drugs often results in drug-induced organ damage, which is mostly undetected and under-reported. The study aimed at evaluating the effect of selected antidepressants on organs and blood cell counts in adult albino rats. Materials and Methods: Adult rats were divided into four groups (n = 5): Group 1 (5 mL/kg of body weight/day normal saline), Group 2 (1 mg/kg of body weight/day risperidone), Group 3 (5 mg/kg of body weight/day fluoxetine), and Group 4 (15 mg/kg of body weight/day imipramine) for 14 days. The animals experienced different stressors during the treatment period to simulate physiological state of depression. On the 14th day, the animals were exposed to the forced swimming test 1 h after the respective treatments. On the 15th day, the animals were sacrificed under halothane anesthesia. Blood sample was collected. Liver and kidney were excised for histological examination. Results were analyzed using one-way analysis of variance. Results: Kidney histology was normal for all groups. Risperidone-exposed rats presented with hepatotoxicity with areas of zonal necrosis and partial central vein congestion. Neutrophil (%) was significantly reduced (P < 0.01) in all treatment groups when compared with controls. White blood cell count was significantly increased (P < 0.01) in the imipramine and risperidone treatment groups but significantly reduced (P < 0.01) in the fluoxetine treatment group when compared with controls. Also, the platelet count was significantly increased (P < 0.01) in the fluoxetine group but decreased in imipramine-and risperidone-treated groups. Conclusion: Chronic antidepressant use can cause changes in blood cell counts and drug-induced organ damage; hence, frequent organ function tests and blood count are required in patients undergoing chronic antidepressant therapy.
慢性抗抑郁药的使用:对成年白化大鼠各种器官组织学和血细胞计数的影响
背景:长期使用抗抑郁药物通常会导致药物诱导的器官损伤,而这种损伤大多未被发现和报道不足。本研究旨在评估所选抗抑郁药对成年白化大鼠器官和血细胞计数的影响。材料和方法:成年大鼠分为4组(n=5):第1组(5 mL/kg体重/天生理盐水)、第2组(1 mg/kg体重/天利培酮)、第3组(5 mg/kg体重/天氟西汀)和第4组(15 mg/kg体重/日丙咪嗪),共14天。动物在治疗期间经历了不同的压力源,以模拟抑郁的生理状态。在第14天,动物在各自处理后1小时暴露于强迫游泳试验。第15天,在氟烷麻醉下处死动物。采集血样。切除肝脏和肾脏进行组织学检查。结果采用单因素方差分析法进行分析。结果:各组肾脏组织学均正常。利培酮暴露大鼠表现出肝毒性,区域呈带状坏死和部分中心静脉充血。与对照组相比,所有治疗组的中性粒细胞(%)均显著降低(P<0.01)。与对照组相比,咪嗪和利培酮治疗组的白细胞计数显著增加(P<0.01),但氟西汀治疗组的红细胞计数显著降低(P<0.01)。此外,氟西汀组的血小板计数显著增加(P<0.01),而丙咪嗪和利培酮治疗组的血小板数下降。结论:长期使用抗抑郁药可引起血细胞计数变化和药物引起的器官损伤;因此,接受慢性抗抑郁治疗的患者需要经常进行器官功能测试和血液计数。
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来源期刊
Journal of Reports in Pharmaceutical Sciences
Journal of Reports in Pharmaceutical Sciences Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)
CiteScore
1.40
自引率
0.00%
发文量
0
期刊介绍: The Journal of Reports in Pharmaceutical Sciences(JRPS) is a biannually peer-reviewed multi-disciplinary pharmaceutical publication to serve as a means for scientific information exchange in the international pharmaceutical forum. It accepts novel findings that contribute to advancement of scientific knowledge in pharmaceutical fields that not published or under consideration for publication anywhere else for publication in JRPS as original research article. all aspects of pharmaceutical sciences consist of medicinal chemistry, molecular modeling, drug design, pharmaceutics, biopharmacy, pharmaceutical nanotechnology, pharmacognosy, natural products, pharmaceutical biotechnology, pharmacology, toxicology and clinical pharmacy.
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